Difference between revisions of "Retinoblastoma"
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| Caption = Retinoblastoma. (WC) | | Caption = Retinoblastoma. (WC) | ||
| Synonyms = | | Synonyms = | ||
| Micro = [[small round cell tumour]] | | Micro = [[small round cell tumour]], Flexner-Wintersteiner [[rosette]]s | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = retinocytoma, other [[small round cell tumours]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 13: | Line 13: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = white, solid, friable | ||
| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
Revision as of 03:53, 9 February 2016
| Retinoblastoma | |
|---|---|
| Diagnosis in short | |
 Retinoblastoma. (WC) | |
|
| |
| LM | small round cell tumour, Flexner-Wintersteiner rosettes |
| LM DDx | retinocytoma, other small round cell tumours |
| Gross | white, solid, friable |
| Site | eye |
|
| |
| Prevalence | rare |
Retinoblastoma is malignant tumour the of the eye.
General
Gross
- White, solid.
- Patterns:
- Endophytic - grow into the vitreous cavity.
- Exophytic - grow toward choroid.
- Mixed - components of endophytic and exophytic.
Note:
- Tumour is extremely friable.
Image
Microscopic
Features:
- Small round cell tumour:
- Scant cytoplasm.
- Flexner-Wintersteiner rosette - key feature.
- Rosette with empty centre (donut hole).[2]
- +/-Homer-Wright rosette.[3]
- Circular rosette with neuropil at the centre.[2]
- Mitoses - common.
- +/-Necrosis.
- +/-Calcification.
DDx:
- Retinocytoma (retinoma) - benign counterpart of retinoblastoma.
Notes:
- DDx of Flexner-Wintersteiner rosette includes:
- Pineoblastoma.
- Medulloepithelioma.
Images
Retinoblastoma. (WC)