Difference between revisions of "Florid epithelial hyperplasia"
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'''Florid epithelial hyperplasia''' is a common benign [[breast pathology]] finding that is associated with a mild increased risk of [[breast cancer]]. | |||
It is also known as '''florid epithelial hyperplasia of the usual type''' (abbreviated '''FEHUT''') and '''usual ductal hyperplasia''' (abbreviated '''UDH'''). | |||
Confusingly, it may be referred to as ''epithelial hyperplasia'', term that is best avoided, as it could lead to confusion with ''[[mild epithelial hyperplasia]]''. | |||
==General== | |||
*Mild increased risk of malignancy ~ 1.5-2x.<ref>{{Ref PCPBoD8|542}}</ref> | |||
*Has to be separated from ''[[mild epithelial hyperplasia]]''. | |||
Note: | |||
*''Moderate epithelial hyperplasia'' redirects to this section. | |||
**It is generally not separated from FEH, as the prognosis is thought to be the same. | |||
==Microscopic== | |||
Features:<ref>{{Ref BP|159-160}}</ref> | |||
*Breast glands with ''more than'' four cell layers above the basement membrane - '''key feature'''. | |||
*Irregular cell spacing; streaming. | |||
*Slit-like lumina, esp. at the periphery of the duct. | |||
*No [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid). | |||
*No nuclear atypia - usually no [[nucleoli]]. | |||
Memory device ''CLEAN'': | |||
*'''C'''ell spacing is irregular, '''L'''umina are slit-like, '''E'''xtent is less than 2 mm or 2 ducts, '''A'''rchitecture ''not'' DCIS-like, '''N'''uclear atypia ''not'' present. | |||
DDx: | |||
*[[Mild epithelial hyperplasia]]. | |||
*[[Atypical ductal hyperplasia]]. | |||
*Cribriform [[ductal carcinoma in situ]] | |||
==Sign out== | |||
<pre> | |||
A. Right Breast (570 grams), Reduction Mammoplasty: | |||
- Benign breast tissue with proliferative fibrocystic changes. | |||
- Benign skin. | |||
B. Left Breast (580 grams), Reduction Mammoplasty: | |||
- Breast tissue and skin within normal limits. | |||
</pre> | |||
Note: | |||
*"Proliferative fibrocystic changes" = UDH + [[fibrocystic changes]]. | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||
Revision as of 16:24, 14 October 2015
Florid epithelial hyperplasia is a common benign breast pathology finding that is associated with a mild increased risk of breast cancer.
It is also known as florid epithelial hyperplasia of the usual type (abbreviated FEHUT) and usual ductal hyperplasia (abbreviated UDH).
Confusingly, it may be referred to as epithelial hyperplasia, term that is best avoided, as it could lead to confusion with mild epithelial hyperplasia.
General
- Mild increased risk of malignancy ~ 1.5-2x.[1]
- Has to be separated from mild epithelial hyperplasia.
Note:
- Moderate epithelial hyperplasia redirects to this section.
- It is generally not separated from FEH, as the prognosis is thought to be the same.
Microscopic
Features:[2]
- Breast glands with more than four cell layers above the basement membrane - key feature.
- Irregular cell spacing; streaming.
- Slit-like lumina, esp. at the periphery of the duct.
- No DCIS-like architecture (not cribriform, not papillary, not micropapillary, not solid).
- No nuclear atypia - usually no nucleoli.
Memory device CLEAN:
- Cell spacing is irregular, Lumina are slit-like, Extent is less than 2 mm or 2 ducts, Architecture not DCIS-like, Nuclear atypia not present.
DDx:
Sign out
A. Right Breast (570 grams), Reduction Mammoplasty: - Benign breast tissue with proliferative fibrocystic changes. - Benign skin. B. Left Breast (580 grams), Reduction Mammoplasty: - Breast tissue and skin within normal limits.
Note:
- "Proliferative fibrocystic changes" = UDH + fibrocystic changes.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 542. ISBN 978-1416054542.
- ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 159-160. ISBN 978-0443066801.