Difference between revisions of "Urinary bladder xanthoma"

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'''Urinary bladder xanthoma''', also '''[[xanthoma]] of the [[urinary bladder]]''' and '''bladder xanthoma''', is a rare benign lesion of the bladder that occasionally may be clinically suspicious for [[malignancy]].<ref name=pmid24810457>{{Cite journal  | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue =  | pages =  | month =  | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref>
'''Urinary bladder xanthoma''', also '''[[xanthoma]] of the urinary bladder''' and '''bladder xanthoma''', is a rare benign lesion of the [[urinary bladder|bladder]] that occasionally may be clinically suspicious for [[malignancy]].<ref name=pmid24810457>{{Cite journal  | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue =  | pages =  | month =  | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref>


==General==
==General==

Revision as of 04:46, 24 July 2015

Urinary bladder xanthoma
Diagnosis in short

Urinary bladder xanthoma. H&E stain.
LM aggregate of foamy histiocytes in the lamina propria, no significant nuclear atypia
LM DDx signet ring cell carcinoma, granular cell tumour, malakoplakia, xanthogranulomatous cystitis, benign urothelium with mild atypia
IHC CD68 +ve, S-100 -ve
Site urinary bladder (elsewhere)
Associated Dx lipid disorders (hyperlipidemia)
Signs +/-hematuria
Symptoms irritation
Prevalence very rare
Endoscopy patch or plaque, yellow, ill-defined border
Prognosis benign

Urinary bladder xanthoma, also xanthoma of the urinary bladder and bladder xanthoma, is a rare benign lesion of the bladder that occasionally may be clinically suspicious for malignancy.[1]

General

  • Rare.
  • Like other xanthomas may be associated with abnormal lipid profile.

Presentation:[2]

  • Hematuria.
  • Irritation.

Gross

Features:[2]

  • Flat lesion (patch or plaque) with ill-defined border, yellow.

Microscopic

Features:

  • Aggregate of foamy histiocytes in the lamina propria.[2]
  • No significant nuclear atypia.

DDx:[2]

Images

  • UBX - low mag.

  • UBX - intermed. mag.

  • UBX - high mag.

  • UBX - very high mag.

  • UBX - intermed. mag.

  • UBX - high mag.

IHC

  • CD68 +ve.
  • S-100 -ve
    • Positive in granular cell tumour.

Sign out

Urinary Bladder Lesion, Transurethral Excision:
- Xanthoma, see comment.
- Negative for carcinoma in situ and negative for invasive malignancy.

COMMENT:
These lesions may be associated metabolic abnormalities. A lipid profile 
should be considered.

See also

References

  1. ↑ Hassouna, H.; Broome, JD.; Swalem, K.; Manikandan, R. (2014). "Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy.". BMJ Case Rep 2014. doi:10.1136/bcr-2014-203836. PMID 24810457.
  2. ↑ 2.0 2.1 2.2 2.3 Yu, DC.; Patel, P.; Bonert, M.; Carlson, K.; Yilmaz, A.; Paner, G.; Magi-Galluzzi, C.; Lopez-Beltran, A. et al. (Aug 2015). "Urinary bladder xanthoma: a multi-institutional series of 17 cases.". Histopathology 67 (2): 255-61. doi:10.1111/his.12647. PMID 25580863.
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