Difference between revisions of "Testicular adrenal rest tumour"
Jump to navigation
Jump to search
(tweak) |
|||
| Line 56: | Line 56: | ||
==IHC== | ==IHC== | ||
*Melan A +ve.<ref name=pmid20951518>{{Cite journal | last1 = Mizukami | first1 = H. | last2 = Hamamatsu | first2 = A. | last3 = Mori | first3 = S. | last4 = Hara | first4 = S. | last5 = Kuroda | first5 = M. | last6 = Nagai | first6 = T. | last7 = Fukunaga | first7 = T. | title = Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year. | journal = Forensic Sci Int | volume = 206 | issue = 1-3 | pages = e71-5 | month = Mar | year = 2011 | doi = 10.1016/j.forsciint.2010.09.017 | PMID = 20951518 }}</ref> | *Melan A +ve.<ref name=pmid20951518>{{Cite journal | last1 = Mizukami | first1 = H. | last2 = Hamamatsu | first2 = A. | last3 = Mori | first3 = S. | last4 = Hara | first4 = S. | last5 = Kuroda | first5 = M. | last6 = Nagai | first6 = T. | last7 = Fukunaga | first7 = T. | title = Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year. | journal = Forensic Sci Int | volume = 206 | issue = 1-3 | pages = e71-5 | month = Mar | year = 2011 | doi = 10.1016/j.forsciint.2010.09.017 | PMID = 20951518 }}</ref> | ||
==Molecular== | |||
*Molecular characteristics are in keeping with adrenal tissue; however, some Leydig cell markers active.<ref name=pmid25485724>{{Cite journal | last1 = Smeets | first1 = EE. | last2 = Span | first2 = PN. | last3 = van Herwaarden | first3 = AE. | last4 = Wevers | first4 = RA. | last5 = Hermus | first5 = AR. | last6 = Sweep | first6 = FC. | last7 = Claahsen-van der Grinten | first7 = HL. | title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. | journal = J Clin Endocrinol Metab | volume = 100 | issue = 3 | pages = E524-30 | month = Mar | year = 2015 | doi = 10.1210/jc.2014-2036 | PMID = 25485724 }}</ref> | |||
==See also== | ==See also== | ||
| Line 61: | Line 64: | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Testis]] | [[Category:Testis]] | ||
Revision as of 02:27, 15 July 2015
| Testicular adrenal rest tumour | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) nuclear atypia |
| LM DDx | Leydig cell tumour |
| IHC | melan A +ve |
| Site | testis |
|
| |
| Associated Dx | congenital adrenal hyperplasia |
| Signs | testicular masses (bilateral) |
| Prevalence | extremely rare |
| Blood work | serum ACTH elevated |
Testicular adrenal rest tumour, abbreviated TART, is a rare tumour associated with increased adrenocorticotropic hormone (ACTH), typically seen in the context of congenital adrenal hyperplasia.[1]
General
- Very rare.
- Benign.[2]
- May overlap with Leydig cell tumour - see molecular section.
Clinical:
- Serum ACTH elevated.
Gross
- Bilateral testicular masses.
Microscopic
Features:
- Nests of eosinophilic cells interspersed with thin bands of fibrous tissue.
- Mild (endocrine) nuclear atypia.
DDx:
- Leydig cell tumour - history different.
Images
IHC
- Melan A +ve.[3]
Molecular
- Molecular characteristics are in keeping with adrenal tissue; however, some Leydig cell markers active.[2]
See also
References
- ↑ Olpin, JD.; Witt, B. (Feb 2014). "Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia.". J Radiol Case Rep 8 (2): 46-53. doi:10.3941/jrcr.v8i2.1489. PMID 24967019.
- ↑ 2.0 2.1 Smeets, EE.; Span, PN.; van Herwaarden, AE.; Wevers, RA.; Hermus, AR.; Sweep, FC.; Claahsen-van der Grinten, HL. (Mar 2015). "Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features.". J Clin Endocrinol Metab 100 (3): E524-30. doi:10.1210/jc.2014-2036. PMID 25485724.
- ↑ Mizukami, H.; Hamamatsu, A.; Mori, S.; Hara, S.; Kuroda, M.; Nagai, T.; Fukunaga, T. (Mar 2011). "Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year.". Forensic Sci Int 206 (1-3): e71-5. doi:10.1016/j.forsciint.2010.09.017. PMID 20951518.