Difference between revisions of "Nested urothelial cell carcinoma"
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'''Nested urothelial cell carcinoma''', also '''nested urothelial carcinoma''', is an aggressive subtype of [[urothelial carcinoma]] that has a bland morphology but an aggressive behaviour. | |||
It is also known as '''nested variant urothelial cell carcinoma'''. | |||
==General== | |||
*Aggressive behaviour despite bland histomorphology.<ref name=pmid14681330>{{Cite journal | last1 = Lin | first1 = O. | last2 = Cardillo | first2 = M. | last3 = Dalbagni | first3 = G. | last4 = Linkov | first4 = I. | last5 = Hutchinson | first5 = B. | last6 = Reuter | first6 = VE. | title = Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. | journal = Mod Pathol | volume = 16 | issue = 12 | pages = 1289-98 | month = Dec | year = 2003 | doi = 10.1097/01.MP.0000094091.04541.FC | PMID = 14681330 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid2712189>{{Cite journal | last1 = Talbert | first1 = ML. | last2 = Young | first2 = RH. | title = Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. | journal = Am J Surg Pathol | volume = 13 | issue = 5 | pages = 374-81 | month = May | year = 1989 | doi = | PMID = 2712189 }}</ref> | |||
*High density of well-circumscribed nests. | |||
*Mild-to-moderate nuclear atypia. | |||
*+/-Foci of unequivocal conventional urothelial carcinoma. | |||
**Focally solid or gland fusion. | |||
**Moderate-to-severe nuclear atypia +/- abundant mitoses. | |||
*+/-Extension into the muscularis propria. | |||
DDx: | |||
*[[von Brunn nests]].<ref name=pmid21836490>{{Cite journal | last1 = Cox | first1 = R. | last2 = Epstein | first2 = JI. | title = Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. | journal = Am J Surg Pathol | volume = 35 | issue = 9 | pages = 1337-42 | month = Sep | year = 2011 | doi = 10.1097/PAS.0b013e318222a653 | PMID = 21836490 }}</ref> | |||
*[[Low grade papillary urothelial carcinoma]] with lamina propria invasion. | |||
==IHC== | |||
*MIB-1 typically >15%.<ref name=pmid14681330/> | |||
==See also== | |||
*[[Urothelial carcinoma]]. | |||
*[[Urothelium]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Urothelium]] | |||
Revision as of 05:50, 19 June 2015
Nested urothelial cell carcinoma, also nested urothelial carcinoma, is an aggressive subtype of urothelial carcinoma that has a bland morphology but an aggressive behaviour.
It is also known as nested variant urothelial cell carcinoma.
General
- Aggressive behaviour despite bland histomorphology.[1]
Microscopic
Features:[2]
- High density of well-circumscribed nests.
- Mild-to-moderate nuclear atypia.
- +/-Foci of unequivocal conventional urothelial carcinoma.
- Focally solid or gland fusion.
- Moderate-to-severe nuclear atypia +/- abundant mitoses.
- +/-Extension into the muscularis propria.
DDx:
- von Brunn nests.[3]
- Low grade papillary urothelial carcinoma with lamina propria invasion.
IHC
- MIB-1 typically >15%.[1]
See also
References
- ↑ 1.0 1.1 Lin, O.; Cardillo, M.; Dalbagni, G.; Linkov, I.; Hutchinson, B.; Reuter, VE. (Dec 2003). "Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases.". Mod Pathol 16 (12): 1289-98. doi:10.1097/01.MP.0000094091.04541.FC. PMID 14681330.
- ↑ Talbert, ML.; Young, RH. (May 1989). "Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases.". Am J Surg Pathol 13 (5): 374-81. PMID 2712189.
- ↑ Cox, R.; Epstein, JI. (Sep 2011). "Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma.". Am J Surg Pathol 35 (9): 1337-42. doi:10.1097/PAS.0b013e318222a653. PMID 21836490.