Difference between revisions of "Micropapillary urothelial carcinoma"
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*HER2 +ve/-ve.<ref name=pmid25673582/> | *HER2 +ve/-ve.<ref name=pmid25673582/> | ||
*p63 -ve/+ve.<ref name=pmid24993315>{{Cite journal | last1 = Lin | first1 = X. | last2 = Zhu | first2 = B. | last3 = Villa | first3 = C. | last4 = Zhong | first4 = M. | last5 = Kundu | first5 = S. | last6 = Rohan | first6 = SM. | last7 = Yang | first7 = XJ. | title = The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma. | journal = Hum Pathol | volume = 45 | issue = 9 | pages = 1824-9 | month = Sep | year = 2014 | doi = 10.1016/j.humpath.2014.04.015 | PMID = 24993315 }}</ref> | *p63 -ve/+ve.<ref name=pmid24993315>{{Cite journal | last1 = Lin | first1 = X. | last2 = Zhu | first2 = B. | last3 = Villa | first3 = C. | last4 = Zhong | first4 = M. | last5 = Kundu | first5 = S. | last6 = Rohan | first6 = SM. | last7 = Yang | first7 = XJ. | title = The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma. | journal = Hum Pathol | volume = 45 | issue = 9 | pages = 1824-9 | month = Sep | year = 2014 | doi = 10.1016/j.humpath.2014.04.015 | PMID = 24993315 }}</ref> | ||
*p40 -ve/+ve.< | *p40 -ve/+ve.<ref name=pmid24993315/> | ||
*GATA3 +ve.< | *GATA3 +ve.<ref name=pmid24993315/> | ||
==Sign out== | ==Sign out== | ||
Revision as of 09:19, 15 June 2015
Micropapillary urothelial carcinoma is an aggressive variant of urothelial carcinoma.[1]
General
Microscopic
Features:[1]
- Micropapillae.
- Quantity of micropapillary (percentage) is variable.[2]
- Conventional urothelial carcinoma (typical).
DDx:
- Metastasis (breast, ovary, lung, pancreas, salivary gland).
Images
Case
UCCMPF - low mag.
UCCMPF - low mag.
UCCMPF - intermed. mag.
UCCMPF - high mag.
UCCMPF - high mag.
UCCMPF - very high mag.
www
IHC
Features:
- CK7 +ve.[2]
- CK20 +ve/-ve.[2]
- EMA +ve.[2]
- HER2 +ve/-ve.[2]
- p63 -ve/+ve.[3]
- p40 -ve/+ve.[3]
- GATA3 +ve.[3]
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- Report percentage of micropapillary pattern - suggested.[citation needed]
See also
References
- ↑ 1.0 1.1 1.2 Compérat, E.; Roupret, M.; Yaxley, J.; Reynolds, J.; Varinot, J.; Ouzaïd, I.; Cussenot, O.; Samaratunga, H. (Dec 2010). "Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases.". Pathology 42 (7): 650-4. doi:10.3109/00313025.2010.522173. PMID 21080874.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chatterjee, D.; Das, A.; Radotra, BD.. "Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study.". Indian J Pathol Microbiol 58 (1): 2-6. doi:10.4103/0377-4929.151153. PMID 25673582.
- ↑ 3.0 3.1 3.2 Lin, X.; Zhu, B.; Villa, C.; Zhong, M.; Kundu, S.; Rohan, SM.; Yang, XJ. (Sep 2014). "The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma.". Hum Pathol 45 (9): 1824-9. doi:10.1016/j.humpath.2014.04.015. PMID 24993315.