Difference between revisions of "Miscellaneous ovarian tumours"
Jump to navigation
Jump to search
Jensflorian (talk | contribs) (→Ovarian small cell carcinoma of the hypercalcemic type: +proposal and link) |
|||
| Line 7: | Line 7: | ||
*Abbreviated ''OSSCHT''. | *Abbreviated ''OSSCHT''. | ||
*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''. | *[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''. | ||
*Proposed name: ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal | last1 = Foulkes | first1 = WD. | last2 = Clarke | first2 = BA. | last3 = Hasselblatt | first3 = M. | last4 = Majewski | first4 = J. | last5 = Albrecht | first5 = S. | last6 = McCluggage | first6 = WG. | title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. | journal = J Pathol | volume = 233 | issue = 3 | pages = 209-14 | month = Jul | year = 2014 | doi = 10.1002/path.4362 | PMID = 24752781 }}</ref> | |||
===General=== | ===General=== | ||
*Hypercalcemia.<ref name=pmid7943531>{{Cite journal | last1 = Young | first1 = RH. | last2 = Oliva | first2 = E. | last3 = Scully | first3 = RE. | title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. | journal = Am J Surg Pathol | volume = 18 | issue = 11 | pages = 1102-16 | month = Nov | year = 1994 | doi = | PMID = 7943531 }}</ref> | *Hypercalcemia.<ref name=pmid7943531>{{Cite journal | last1 = Young | first1 = RH. | last2 = Oliva | first2 = E. | last3 = Scully | first3 = RE. | title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. | journal = Am J Surg Pathol | volume = 18 | issue = 11 | pages = 1102-16 | month = Nov | year = 1994 | doi = | PMID = 7943531 }}</ref> | ||
Revision as of 08:12, 1 April 2015
The article collects miscellaneous ovarian tumours, as per the WHO classification.[1]
Ovarian small cell carcinoma of the pulmonary type
- See: Small cell carcinoma.
Ovarian small cell carcinoma of the hypercalcemic type
- Abbreviated OSSCHT.
- AKA small cell carcinoma, hypercalcemic type, AKA small cell carcinoma of the ovary, hypercalcemic type.
- Proposed name: Malignant rhabdoid tumour of the ovary (MRTO). [2]
General
- Hypercalcemia.[3]
- Very rare.
- Most common undifferentiated ovarian malignancy in individuals less than 40 years old.[4]
- Associated with SMARCA4 mutations - may be familial.[4]
Microscopic
Features:[3]
- Small cell carcinoma.
- Follicle-like spaces.
DDx:
- Small cell carcinoma of the lung.
- Small cell carcinoma of the cervix.
- Sertoli-Leydig cell tumour.
- Juvenile granulosa cell tumour.
Images
www:
OSSCHT - low mag. (WC)
OSSCHT - intermed. mag. (WC)
OSSCHT - high mag. (WC)
OSSCHT - very high mag. (WC)
IHC
Features:[5]
- WT-1 +ve.
- TTF-1 -ve.
- HPV -ve.
- p16 +ve/-ve.
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 403. ISBN 978-0781765275.
- ↑ Foulkes, WD.; Clarke, BA.; Hasselblatt, M.; Majewski, J.; Albrecht, S.; McCluggage, WG. (Jul 2014). "No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour.". J Pathol 233 (3): 209-14. doi:10.1002/path.4362. PMID 24752781.
- ↑ 3.0 3.1 Young, RH.; Oliva, E.; Scully, RE. (Nov 1994). "Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases.". Am J Surg Pathol 18 (11): 1102-16. PMID 7943531.
- ↑ 4.0 4.1 Witkowski L, Carrot-Zhang J, Albrecht S, et al. (May 2014). "Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type". Nat. Genet. 46 (5): 438–43. doi:10.1038/ng.2931. PMID 24658002.
- ↑ Carlson, JW.; Nucci, MR.; Brodsky, J.; Crum, CP.; Hirsch, MS. (Sep 2007). "Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis.". Histopathology 51 (3): 305-12. doi:10.1111/j.1365-2559.2007.02790.x. PMID 17727473.