Difference between revisions of "Subependymal giant cell astrocytoma"

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#redirect [[Neuropathology_tumours#Subependymal giant cell astrocytoma]]
'''Subependymal giant cell astrocytoma''', abbreviated '''SEGA''', is a low-grade astrocytoma associated with [[tuberous sclerosis complex]].
 
==General==
*Associated with [[tuberous sclerosis complex]] (TSC).<ref name=pmid21455842>{{Cite journal  | last1 = Grajkowska | first1 = W. | last2 = Kotulska | first2 = K. | last3 = Jurkiewicz | first3 = E. | last4 = Roszkowski | first4 = M. | last5 = Daszkiewicz | first5 = P. | last6 = Jóźwiak | first6 = S. | last7 = Matyja | first7 = E. | title = Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas. | journal = Folia Neuropathol | volume = 49 | issue = 1 | pages = 39-46 | month =  | year = 2011 | doi =  | PMID = 21455842 }}</ref>
*WHO Grade I.
 
==Gross/radiology==
*Well-demarcated.
 
==Microscopic==
Features:<ref name=upmc_case179/><ref name=pmid9595853>{{Cite journal  | last1 = Taraszewska | first1 = A. | last2 = Kroh | first2 = H. | last3 = Majchrowski | first3 = A. | title = Subependymal giant cell astrocytoma: clinical, histologic and immunohistochemical characteristic of 3 cases. | journal = Folia Neuropathol | volume = 35 | issue = 3 | pages = 181-6 | month =  | year = 1997 | doi =  | PMID = 9595853 }}</ref>
*Giant cells with nuclear atypia ("bizarre cells").
**Vesicular nuclei.
**[[Nuclear pseudoinclusions]].<ref name=upmc179>URL: [http://path.upmc.edu/cases/case179/micro.html http://path.upmc.edu/cases/case179/micro.html]. Accessed on: 8 January 2012.</ref>
*Glassy eosinophilic cytoplasm.
*Abundant [[mast cell]]s.<ref name=upmc179>URL: [http://path.upmc.edu/cases/case179/micro.html http://path.upmc.edu/cases/case179/micro.html]. Accessed on: 8 January 2012.</ref>
 
Images:
*[http://path.upmc.edu/cases/case179/micro.html SEGA (upmc.edu)].<ref name=upmc_case179>URL: [http://path.upmc.edu/cases/case179.html http://path.upmc.edu/cases/case179.html]. Accessed on: 29 July 2011.</ref>
*[http://path.upmc.edu/cases/case500.html SEGA - another case (upmc.edu)].
 
==IHC==
Features:<ref name=pmid9595853/>
*GFAP +ve. (???)
*Vimentin +ve. (???)
*S100 +ve. (???)
 
==See also==
*[[Neuropathology tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Neuropathology tumours]]

Revision as of 05:49, 10 December 2014

Subependymal giant cell astrocytoma, abbreviated SEGA, is a low-grade astrocytoma associated with tuberous sclerosis complex.

General

Gross/radiology

  • Well-demarcated.

Microscopic

Features:[2][3]

Images:

IHC

Features:[3]

  • GFAP +ve. (???)
  • Vimentin +ve. (???)
  • S100 +ve. (???)

See also

References

  1. ↑ Grajkowska, W.; Kotulska, K.; Jurkiewicz, E.; Roszkowski, M.; Daszkiewicz, P.; Jóźwiak, S.; Matyja, E. (2011). "Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas.". Folia Neuropathol 49 (1): 39-46. PMID 21455842.
  2. ↑ 2.0 2.1 URL: http://path.upmc.edu/cases/case179.html. Accessed on: 29 July 2011.
  3. ↑ 3.0 3.1 Taraszewska, A.; Kroh, H.; Majchrowski, A. (1997). "Subependymal giant cell astrocytoma: clinical, histologic and immunohistochemical characteristic of 3 cases.". Folia Neuropathol 35 (3): 181-6. PMID 9595853.
  4. ↑ 4.0 4.1 URL: http://path.upmc.edu/cases/case179/micro.html. Accessed on: 8 January 2012.
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