Difference between revisions of "Clear cell adenocarcinoma of the urethra"

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DDx:
DDx:
*[[Nephrogenic adenoma]]<ref name=pmid23307189/><ref name=pmid21496868>{{Cite journal  | last1 = Brimo | first1 = F. | last2 = Herawi | first2 = M. | last3 = Sharma | first3 = R. | last4 = Netto | first4 = GJ. | last5 = Epstein | first5 = JI. | last6 = Illei | first6 = PB. | title = Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. | journal = Hum Pathol | volume = 42 | issue = 11 | pages = 1613-9 | month = Nov | year = 2011 | doi = 10.1016/j.humpath.2011.01.007 | PMID = 21496868 }}</ref> - also has hobnailing.
*[[Nephrogenic adenoma]]<ref name=pmid23307189/><ref name=pmid21496868>{{Cite journal  | last1 = Brimo | first1 = F. | last2 = Herawi | first2 = M. | last3 = Sharma | first3 = R. | last4 = Netto | first4 = GJ. | last5 = Epstein | first5 = JI. | last6 = Illei | first6 = PB. | title = Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. | journal = Hum Pathol | volume = 42 | issue = 11 | pages = 1613-9 | month = Nov | year = 2011 | doi = 10.1016/j.humpath.2011.01.007 | PMID = 21496868 }}</ref> - also has hobnailing, not mitotically active, no necrosis, no or mild [[nuclear atypia]].
*[[Clear cell renal cell carcinoma]].
*[[Clear cell renal cell carcinoma]].
*[[Clear cell adenocarcinoma]] of the gynecologic tract.
*[[Clear cell adenocarcinoma]] of the gynecologic tract.

Revision as of 20:59, 13 November 2014

Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.

General

  • Predominantly in women.[1]

Pathogenesis not well understood - may arise from:

Microscopic

Features:[1]

  • Clear cells (at least focally).
  • Hobnailing (classic feature).

Note:

DDx:

Images

www:

IHC

Features:[2]

  • PAX8 +ve/-ve (2 +ve in 4 cases.
  • CK7 +ve/-ve (2 +ve in 4 cases).
  • Vimentin +ve (3 +ve in 4 cases).
  • CK20 -ve/+ve (1 +ve in 4 cases).

Others:[2]

  • ER -ve.
  • p63 -ve.
  • PSA -ve.
  • p16 -ve.
  • Ki-67 ~ 47/200 on average cells.
    • 5.5/200 cells on average in nephrogenic adenoma.[5]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.
  3. ↑ Brimo, F.; Herawi, M.; Sharma, R.; Netto, GJ.; Epstein, JI.; Illei, PB. (Nov 2011). "Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis.". Hum Pathol 42 (11): 1613-9. doi:10.1016/j.humpath.2011.01.007. PMID 21496868.
  4. ↑ Han, JY.; Kim, KH.; Kim, L.; Choi, SJ.; Park, IS.; Kim, JM.; Chu, YC.; Yoon, SM. (Apr 2012). "Cytologic findings of clear cell adenocarcinoma of the urethra: a case report.". Korean J Pathol 46 (2): 210-4. doi:10.4132/KoreanJPathol.2012.46.2.210. PMID 23110004.
  5. ↑ Gilcrease, MZ.; Delgado, R.; Vuitch, F.; Albores-Saavedra, J. (Dec 1998). "Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison.". Hum Pathol 29 (12): 1451-6. PMID 9865832.
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