Lung metastasis: Difference between revisions
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Created page with "'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis. ==General== *Relatively..." |
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*Variable - dependent on site of origin. | *Variable - dependent on site of origin. | ||
[[Colorectal adenocarcinoma]]: | [[Colorectal adenocarcinoma]] - usually distinctive morphologically: | ||
*Typically gland forming. | *Typically gland forming. | ||
**Ellipsoid/elongated pseudostratified nuclei with moderate [[nuclear atypia]]. | **Ellipsoid/elongated pseudostratified nuclei with moderate [[nuclear atypia]]. | ||
**+/-Dirty necrosis. | **+/-Dirty necrosis. | ||
Others: | |||
*[[Urothelial carcinoma]] - may mimic [[squamous cell carcinoma of the lung]]. | |||
*Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]]. | |||
*Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]]. | |||
==IHC== | ==IHC== | ||
Revision as of 19:20, 29 September 2014
Lung metastasis, also pulmonary metastasis and metastatic lung disease, is relatively common and generally carries a poor prognosis.
General
- Relatively common.
Microscopic
Features:
- Variable - dependent on site of origin.
Colorectal adenocarcinoma - usually distinctive morphologically:
- Typically gland forming.
- Ellipsoid/elongated pseudostratified nuclei with moderate nuclear atypia.
- +/-Dirty necrosis.
Others:
- Urothelial carcinoma - may mimic squamous cell carcinoma of the lung.
- Upper GI adenocarcinoma (e.g. gastric adenocarcinoma) - may mimic lung adenocarcinoma.
- Breast carcinoma - esp. ductal carcinoma of the breast - may mimic lung adenocarcinoma.
IHC
- TTF-1 -ve (may be positive).
- CK20 +ve/-ve (+ve in colorectal carcinoma, -ve in lung primaries).
- GATA3 +ve/-ve (usu. +ve in urothelial carcinoma, -ve in lung primaries[1]).
See also
References
- ↑ Chang, A.; Amin, A.; Gabrielson, E.; Illei, P.; Roden, RB.; Sharma, R.; Epstein, JI. (Oct 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung.". Am J Surg Pathol 36 (10): 1472-6. doi:10.1097/PAS.0b013e318260cde7. PMID 22982890.