Difference between revisions of "Uterine tubes"
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#*Nucleus more luminal. | #*Nucleus more luminal. | ||
#**Nuclei stick-out like a golf tee. | #**Nuclei stick-out like a golf tee. | ||
#Secretory cells. | #Secretory cells. (???) | ||
#*Basal cells, fried egg-like. | #*Basal cells, fried egg-like. | ||
Revision as of 17:42, 21 August 2014
Uterine tubes, also known as the Fallopian tubes, serve as a connection between the ovaries and the uterus. It is where fertilization usually takes place.
This was ignored in the past... current thinking is that it may be the real culprit in what is often labeled as "ovarian cancer".[1]
Normal uterine tube
Architecture:
- Finger-like projections into the lumen.
Cells:
- Ciliated cell.
- Columnar.
- Eosinophilic cytoplasm.
- Non-ciliated cell (AKA Peg cell).
- Nucleus more luminal.
- Nuclei stick-out like a golf tee.
- Nucleus more luminal.
- Secretory cells. (???)
- Basal cells, fried egg-like.
Images:
- Fallopian tube (une.edu).[2]
- Fallopian tube (medpics.ucsd.edu).
- Uterine tube - cells (ouhsc.edu).
- Uterine tube - wall (ouhsc.edu).
Overview
Benign lesions
Benign neoplasm
Pre-malignant
Malignant diagnoses
- Serous carcinoma.
- Endometrioid adenocarcinoma.[3]
Ditzels
Main article: Ditzels
Paratubal cyst
General
- Very common.
- May lead to ovarian torsion if very large.[4]
Gross
- Thin walled-cyst with serous fluid.
Microscopic
Features:
- Simple cyst with ciliated (tubal) epithelium.
Sign out
PARATUBAL CYST, RIGHT, EXCISION: - BENIGN SIMPLE CYST.
No epithelium
PARATUBAL CYST, LEFT, EXCISION: - BENIGN FIBROUS TISSUE COMPATIBLE WITH CYST WALL.
Tubal ligation
- Abbreviated TL.
General
- Done to control fertility.
Microscopic
See normal uterine tube.
DDx:
- Salpingitis - inflammatory cells.
- Serous carcinoma - nuclear atypia (marked), nuclear pleomorphism, prominent nucleoli.
- Tubal intraepithelial carcinoma - discrete papillary growth, loss of nuclear polarity, nuclear atypia.
- Endometriosis.
Sign out
Left then right
A. FALLOPIAN TUBE, LEFT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS, CONSISTENT WITH COMPLETE CROSS SECTIONS. B. FALLOPIAN TUBE, RIGHT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS, CONSISTENT WITH COMPLETE CROSS SECTIONS.
A. FALLOPIAN TUBE, LEFT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS. B. FALLOPIAN TUBE, RIGHT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS.
Right then left
A. FALLOPIAN TUBE, RIGHT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS, CONSISTENT WITH COMPLETE CROSS SECTIONS. B. FALLOPIAN TUBE, LEFT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS, CONSISTENT WITH COMPLETE CROSS SECTIONS.
A. FALLOPIAN TUBE, RIGHT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS. B. FALLOPIAN TUBE, LEFT, TUBAL LIGATION: - FALLOPIAN TUBE WITHIN NORMAL LIMITS.
Surgical resection of previous tubal ligation
LEFT FALLOPIAN TUBE AND OVARY, LEFT SALPINGO-OOPHORECTOMY: - FALLOPIAN TUBE WITH PARATUBAL CYSTS AND FOCAL FIBROSIS. - OVARY WITHIN NORMAL LIMITS.
Specific diagnoses
Salpingitis
- Also suppurative salpingitis.
- Also granulomatous salpingitis.
General
- Benign.
- May be part of pelvic inflammatory disease.
Microscopic
Features:
- Inflammatory cells:
- Neutrophils = acute.
- Lymphocytes and plasma cells = chronic.
- +/-Granulomas; known as granulomatous salpingitis.
- +/-Clusters of neutrophils = abscess; known as suppurative salpingitis.
Images:
- Salpingitis - low mag. (WC).
- Salpingitis - high mag. (WC).
- Granulomatous salpingitis - intermed mag. (WC).
- Granulomatous salpingitis - high mag. (WC).
Stains
If organisms are seen on routine stains:
- Gram stain +ve/-ve.
Granulomatous inflammation:
- Ziehl-Neelsen stain +ve/-ve.
- GMS stain +ve/-ve.
- PASD stain +ve/-ve.
Adenofibroma
General
- Rare.[5]
- More frequently seen than in the past -- presumably as pathologists are looking more closely at the Fallopian tube.
- Cannot be disguished from ovarian adenofibroma.[5]
Gross
- Solid, nodular.
Microscopic
Features:[5]
- Stroma + glandular elements.
- Glandular elements: secretory cells and ciliated cells.
IHC
Features:
- Stroma:[5]
- CD10 +ve.
- Inhibin +ve.
Salpingitis isthmica nodosa
General
- Associated with infertility and ectopic pregnancy.[8]
- SIN is uncommonly bilateral.[9]
Diagnosis (clinical):
- Hysterosalpingography.[10]
- Finding: diverticula.
Notes:
- The male cousin of this is: vasitis nodosa.
Microscopic
Features:[11]
- Nodular thickening of the tunica muscularis of the isthmic portion.
- Cystically dilated glands.
- +/-Complete obliteration of tubal lumen.
Images:
Adenomatoid tumour
See: Adenomatoid tumours (uterine tumours).
General
- Relatively common tumour of the fallopian tube.[12]
Microscopic
See: Adenomatoid tumours (uterine tumours).
Serous tubal intraepithelial carcinoma
Main article: Serous tubal intraepithelial carcinoma
See also
References
- ↑ Hirst, JE.; Gard, GB.; McIllroy, K.; Nevell, D.; Field, M. (Jul 2009). "High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy.". Int J Gynecol Cancer 19 (5): 826-9. doi:10.1111/IGC.0b013e3181a1b5dc. PMID 19574767.
- ↑ URL: http://faculty.une.edu/com/abell/histo/histolab3f.htm. Accessed on: 18 October 2011.
- ↑ Navani, SS.; Alvarado-Cabrero, I.; Young, RH.; Scully, RE. (Dec 1996). "Endometrioid carcinoma of the fallopian tube: a clinicopathologic analysis of 26 cases.". Gynecol Oncol 63 (3): 371-8. doi:10.1006/gyno.1996.0338. PMID 8946874.
- ↑ Thakore, SS.; Chun, MJ.; Fitzpatrick, K. (Aug 2012). "Recurrent ovarian torsion due to paratubal cysts in an adolescent female.". J Pediatr Adolesc Gynecol 25 (4): e85-7. doi:10.1016/j.jpag.2011.10.012. PMID 22840942.
- ↑ 5.0 5.1 5.2 5.3 Bossuyt, V.; Medeiros, F.; Drapkin, R.; Folkins, AK.; Crum, CP.; Nucci, MR. (Jul 2008). "Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma.". Int J Gynecol Pathol 27 (3): 390-7. doi:10.1097/PGP.0b013e3181639a82. PMID 18580316.
- ↑ Stedman's Medical Dictionary. 27th Ed. Lippincott Williams & Wilkins.
- ↑ URL: http://www.medcyclopaedia.com/library/topics/volume_iv_2/s/salpingitis_isthmica_nodosa.aspx. Accessed on: 28 July 2010.
- ↑ Jenkins, CS.; Williams, SR.; Schmidt, GE. (Oct 1993). "Salpingitis isthmica nodosa: a review of the literature, discussion of clinical significance, and consideration of patient management.". Fertil Steril 60 (4): 599-607. PMID 8405510.
- ↑ Skibsted, L.; Sperling, L.; Hansen, U.; Hertz, J. (Jul 1991). "Salpingitis isthmica nodosa in female infertility and tubal diseases.". Hum Reprod 6 (6): 828-31. PMID 1757522.
- ↑ URL: http://radiology.rsna.org/content/154/3/597.abstract. Accessed on: 28 July 2010.
- ↑ Chawla, N.; Kudesia, S.; Azad, S.; Singhal, M.; Rai, SM.. "Salpingitis isthmica nodosa.". Indian J Pathol Microbiol 52 (3): 434-5. doi:10.4103/0377-4929.55019. PMID 19679986.
- ↑ Christensen C (1990). "Adenomatoid tumors of the uterus". Eur. J. Gynaecol. Oncol. 11 (2): 85–9. PMID 2199199.
- ↑ Visvanathan, K.; Vang, R.; Shaw, P.; Gross, A.; Soslow, R.; Parkash, V.; Shih, IeM.; Kurman, RJ. (Dec 2011). "Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study.". Am J Surg Pathol 35 (12): 1766-75. doi:10.1097/PAS.0b013e31822f58bc. PMID 21989347.