Difference between revisions of "Paneth cell"

From Libre Pathology
Jump to navigation Jump to search
Line 2: Line 2:


==General==
==General==
*Paneth cell distal to the splenic flexure are abnormal.
*Paneth cells should ''not'' be in the left colon<ref name=pmid11851832>{{cite journal |author=Tanaka M, Saito H, Kusumi T, ''et al'' |title=Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease |journal=J. Gastroenterol. Hepatol. |volume=16 |issue=12 |pages=1353–9 |year=2001 |month=December |pmid=11851832 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353}}</ref> - if you see 'em think of IBD and other long-standing injurious processes.
**They are indicative of chronic inflammation - seen in [[inflammatory bowel disease]].
*Some claim that (friendly right colonic) paneth cells and paneth cell metaplasia look quite different and can be distinguished.<ref name=pmid12655793>{{cite journal |author=Rubio CA, Nesi G |title=A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections |journal=In Vivo |volume=17 |issue=1 |pages=67–71 |year=2003 |pmid=12655793 |doi= |url=}}</ref>
 


==Microscopic==
==Microscopic==
Line 17: Line 18:
*[[Gastrointestinal pathology]].
*[[Gastrointestinal pathology]].
*[[Colon]].
*[[Colon]].
==References==
{{Reflist|2}}


[[Category:Basics]]
[[Category:Basics]]

Revision as of 00:37, 19 January 2014

The Paneth cell is characteristic of the small intestine. It is also normal in the cecum, ascending colon and transverse colon.

General

  • Paneth cells should not be in the left colon[1] - if you see 'em think of IBD and other long-standing injurious processes.
  • Some claim that (friendly right colonic) paneth cells and paneth cell metaplasia look quite different and can be distinguished.[2]


Microscopic

Features:

  • Supranuclear eosinophilic granules.

DDx:

  • Enterochromaffin cells (AKA Kulchitsky cells).
    • Subnuclear eosinophilic granules.
  • Intraepithelial eosinophils.

See also

References

  1. Tanaka M, Saito H, Kusumi T, et al (December 2001). "Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease". J. Gastroenterol. Hepatol. 16 (12): 1353–9. PMID 11851832. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353.
  2. Rubio CA, Nesi G (2003). "A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections". In Vivo 17 (1): 67–71. PMID 12655793.