Difference between revisions of "Serous cystadenoma of the pancreas"

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#redirect [[Pancreas#Serous cystadenoma of the pancreas]]
'''Serous cystadenoma of the pancreas''' is a benign cystic lesion of the pancreas. It may be seen in [[von Hippel-Lindau disease]].


It is also known as '''serous microcystic adenoma''',<ref name=Ref_Sternberg4_1630>{{Ref Sternberg4|1630}}</ref> and '''pancreatic serous cystadenoma'''.
==General==
*1-2% of all exocrine pancreatic tumours.
*Female > male.
*Mean age 66 years.
*Truly benign with no malignant potenial.
*May be part of [[von Hippel-Lindau syndrome]].
Management:
*Observe or resect.
==Gross==
Features:
*Classically has a characteristic central scar.<ref name=pmid15888617>{{cite journal |author=Kim YH, Saini S, Sahani D, Hahn PF, Mueller PR, Auh YH |title=Imaging diagnosis of cystic pancreatic lesions: pseudocyst versus nonpseudocyst |journal=Radiographics |volume=25 |issue=3 |pages=671–85 |year=2005 |pmid=15888617 |doi=10.1148/rg.253045104 |url=http://radiographics.rsna.org/content/25/3/671.abstract}}</ref>
*Bosulated surface.
*Lobulated.
*No (macroscopic) cysts apparent on gross.
*Location: 50-70% occur in the body and tail.
*Size: average size 11 cm.
Radiologic appearance:
*Honey comb-like appearance.
*Well demarcated border - may be described as a "coin lesion".
Image:
*[http://www.joplink.net/prev/200905/25_fig06.jpg Serous microcystic adenoma (joplink.net)].<ref name=pmid19454830>{{Cite journal  | last1 = Vernadakis | first1 = S. | last2 = Kaiser | first2 = GM. | last3 = Christodoulou | first3 = E. | last4 = Mathe | first4 = Z. | last5 = Troullinakis | first5 = M. | last6 = Bankfalvi | first6 = A. | last7 = Paul | first7 = A. | title = Enormous serous microcystic adenoma of the pancreas. | journal = JOP | volume = 10 | issue = 3 | pages = 332-4 | month =  | year = 2009 | doi =  | PMID = 19454830 |URL = http://www.joplink.net/prev/200905/25.html }}</ref>
==Microscopic==
Features:
*Cystic spaces lined by cuboidal cells.
**Glycogen rich.
**Cilia. (???)
DDx:
*[[Renal cell carcinoma]].
*[[Lymphangioma]].
*[[Hemangioma]].
*Oligocystic mucinous cystic tumors and pseudocysts.
**Have mucin; PAS-D could be used to demonstrate its presence.
Notes:
*Serous adenoma may coexist with aggressive tumours.
===Images===
<gallery>
Image:Pancreatic_serous_cystadenoma_-_low_mag.jpg | PSC - low mag. (WC)
Image:Pancreatic_serous_cystadenoma_-_intermed_mag.jpg | PSC - intermed. mag. (WC)
Image:Pancreatic_serous_cystadenoma_-_high_mag.jpg | PSC - high mag. (WC)
Image:Pancreatic_serous_cystadenoma_-_very_high_mag.jpg | PSC - very high mag. (WC)
</gallery>
==Stains==
*PAS +ve.
*PASD -ve.
==See also==
*[[Pancreas]].
*[[Serous cystadenoma]].
==References==
{{Reflist|2}}
[[Category:Pancreas]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 01:26, 18 January 2014

Serous cystadenoma of the pancreas is a benign cystic lesion of the pancreas. It may be seen in von Hippel-Lindau disease.

It is also known as serous microcystic adenoma,[1] and pancreatic serous cystadenoma.

General

  • 1-2% of all exocrine pancreatic tumours.
  • Female > male.
  • Mean age 66 years.
  • Truly benign with no malignant potenial.
  • May be part of von Hippel-Lindau syndrome.

Management:

  • Observe or resect.

Gross

Features:

  • Classically has a characteristic central scar.[2]
  • Bosulated surface.
  • Lobulated.
  • No (macroscopic) cysts apparent on gross.
  • Location: 50-70% occur in the body and tail.
  • Size: average size 11 cm.

Radiologic appearance:

  • Honey comb-like appearance.
  • Well demarcated border - may be described as a "coin lesion".

Image:

Microscopic

Features:

  • Cystic spaces lined by cuboidal cells.
    • Glycogen rich.
    • Cilia. (???)

DDx:

Notes:

  • Serous adenoma may coexist with aggressive tumours.

Images

  • PSC - low mag. (WC)

  • PSC - intermed. mag. (WC)

  • PSC - high mag. (WC)

  • PSC - very high mag. (WC)

Stains

  • PAS +ve.
  • PASD -ve.

See also

References

  1. ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 1630. ISBN 978-0781740517.
  2. ↑ Kim YH, Saini S, Sahani D, Hahn PF, Mueller PR, Auh YH (2005). "Imaging diagnosis of cystic pancreatic lesions: pseudocyst versus nonpseudocyst". Radiographics 25 (3): 671–85. doi:10.1148/rg.253045104. PMID 15888617. http://radiographics.rsna.org/content/25/3/671.abstract.
  3. ↑ Vernadakis, S.; Kaiser, GM.; Christodoulou, E.; Mathe, Z.; Troullinakis, M.; Bankfalvi, A.; Paul, A. (2009). "Enormous serous microcystic adenoma of the pancreas.". JOP 10 (3): 332-4. PMID 19454830.
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