Difference between revisions of "Proton pump inhibitor effect"
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[[Image:Stomach with PPI effect -- very high mag.jpg|thumb|right|Stomach with PPI effect. [[H&E stain]].]] | [[Image:Stomach with PPI effect -- very high mag.jpg|thumb|right|250px|Stomach with PPI effect. [[H&E stain]].]] | ||
'''Proton pump inhibitor effect''', abbreviated '''PPI effect''', is a change seen in the parietal cells of the [[stomach]] due to a drug in the proton pump inhibitor class. | '''Proton pump inhibitor effect''', abbreviated '''PPI effect''', is a change seen in the parietal cells of the [[stomach]] due to a drug in the proton pump inhibitor class. | ||
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Features:<ref>{{Cite journal | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi = | PMID = 8888719 }}</ref> | Features:<ref>{{Cite journal | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi = | PMID = 8888719 }}</ref> | ||
*Parietal cell enlargement - '''key feature'''. | *Parietal cell enlargement - '''key feature'''. | ||
**Parietal cells typically bulge into the lumen. | |||
===Images=== | ===Images=== | ||
Revision as of 04:43, 12 January 2014
Stomach with PPI effect. H&E stain.
Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.
Formally, it is stomach with proton pump inhibitor effect.
General
- Due to intake of a proton pump inhibitor (PPI).
- Used to treat gastroesophageal reflux disease.
Microscopic
Features:[1]
- Parietal cell enlargement - key feature.
- Parietal cells typically bulge into the lumen.
Images
PPI effect - intermed. mag. (WC)
PPI effect - high mag. (WC)
PPI effect - very high mag. (WC)
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- Usually not reported.