Difference between revisions of "Cutaneous calcinosis"
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Subtypes:<ref name=emed>URL: [http://emedicine.medscape.com/article/1103137-overview http://emedicine.medscape.com/article/1103137-overview]. Accessed on: 21 September 2011.</ref> | Subtypes:<ref name=emed>URL: [http://emedicine.medscape.com/article/1103137-overview http://emedicine.medscape.com/article/1103137-overview]. Accessed on: 21 September 2011.</ref> | ||
#Dystrophic - due to death of cells; may be related to a tumour. | #Dystrophic - due to death of cells; may be related to a tumour. | ||
#Metastatic - due to chronic renal failure; hyperkalemia; paraneoplastic phenomenon. | #Metastatic - due to [[chronic renal failure]]; hyperkalemia; paraneoplastic phenomenon. | ||
#Iatrogenic - post surgical. | #Iatrogenic - post surgical. | ||
#Idiopathic. | #Idiopathic. | ||
Revision as of 13:21, 2 January 2014
| Cutaneous calcinosis | |
|---|---|
| Diagnosis in short | |
 Cutaneous calcinosis. H&E stain. | |
|
| |
| LM | dermal calcification - usu. well-circumscribed |
| Gross | firm nodule |
| Site | skin, scrotum |
|
| |
| Clinical history | +/-trauma at the site |
| Signs | firm nodule |
| Prevalence | uncommon |
| Prognosis | benign |
| Treatment | excision |
Cutaneous calcinosis, also calcinosis cutis, is calcification of the skin. It is benign in itself; however, the underlying cause not be.
General
- Benign in itself; underlying cause may not be benign.
- May be a scrotal lesion - known as scrotal calcinosis.[1]
Subtypes:[2]
- Dystrophic - due to death of cells; may be related to a tumour.
- Metastatic - due to chronic renal failure; hyperkalemia; paraneoplastic phenomenon.
- Iatrogenic - post surgical.
- Idiopathic.
Gross
- Firm nodule.
Microscopic
Features:
- Dermal calcification:
- Acellular purple blobs on H&E.
- +/-Artefactual tearing of surrounding tissue due to processing (cutting).
- +/-Small artefactual lines ~1-2 micrometers due to processing (cutting).
- +/-Greyish rim of paucicellular material.
- Usu. well-circumscribed.
- May be surrounded by a palisading granuloma & giant cells.
- Acellular purple blobs on H&E.
Images
CC - very low mag.
CC - low mag.
CC - intermed. mag.
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SKIN AND SUBCUTANEOUS LESION, LEFT HIP, EXCISION: - SUBCUTANEOUS CALCIFICATION SURROUNDED BY BENIGN FIBROUS TISSUE. - DERMAL SCAR. - NEGATIVE FOR MALIGNANCY.
SUBCUTANEOUS MASS, OVER BURSA OF ELBOW, EXCISION: - CALCINOSIS CUTIS.
Micro
The sections show subcutaneous calcifications surrounded by macrophages and giant cells. No nuclear atypia is apparent. The overlying skin is unremarkable.
See also
References
- ↑ Dubey, S.; Sharma, R.; Maheshwari, V. (2010). "Scrotal calcinosis: idiopathic or dystrophic?". Dermatol Online J 16 (2): 5. PMID 20178701.
- ↑ URL: http://emedicine.medscape.com/article/1103137-overview. Accessed on: 21 September 2011.