Difference between revisions of "Radiation changes"
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'''Radiation changes''', also '''radiation effect''', are seen occasionally by | '''Radiation changes''', also '''radiation effect''', are seen occasionally by [[pathologist]]s. They are usually a result of prior treatments. The history is important in making this diagnosis | ||
==Gross== | ==Gross== | ||
| Line 14: | Line 14: | ||
*+/-Fibrosis (chronic change). | *+/-Fibrosis (chronic change). | ||
*+/-Edema (acute change). | *+/-Edema (acute change). | ||
Important note: | |||
*Pleomorphism is often suggestive of malignancy. Paradoxically, in the context of radiation, less pleomorphic (clonal-appearing) cells may be malignant! | |||
DDx: | DDx: | ||
Revision as of 06:49, 25 September 2013
Radiation changes, also radiation effect, are seen occasionally by pathologists. They are usually a result of prior treatments. The history is important in making this diagnosis
Gross
- +/-Fibrotic appearing tissue.
Microscopic
Features:[1]
- Cytoplasmic vacuolation - usually abundant.
- Nucleus:
- Enlarged nucleus - but normal NC ratio.
- No nuclear membrane irregularies.
- Chromatin: "smudgy".
- +/-Multinucleation.
- +/-Fibrosis (chronic change).
- +/-Edema (acute change).
Important note:
- Pleomorphism is often suggestive of malignancy. Paradoxically, in the context of radiation, less pleomorphic (clonal-appearing) cells may be malignant!
DDx: