Difference between revisions of "Keratocystic odontogenic tumour"
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==General== | ==General== | ||
*May be associated with ''[[nevoid basal cell carcinoma syndrome]]''. | *May be associated with ''[[nevoid basal cell carcinoma syndrome]]''. | ||
*Very rarely transforms to a squamous cell carinoma.<ref name=pmid21493332>{{Cite journal | last1 = Lee | first1 = JW. | last2 = Gates | first2 = R. | last3 = Wignall | first3 = A. | title = Squamous cell carcinoma arising from a keratocystic odontogenic tumor. | journal = Otolaryngol Head Neck Surg | volume = 145 | issue = 2 | pages = 356-7 | month = Aug | year = 2011 | doi = 10.1177/0194599811399270 | PMID = 21493332 }}</ref><ref name=pmid23374486>{{Cite journal | last1 = Tan | first1 = B. | last2 = Yan | first2 = TS. | last3 = Shermin | first3 = L. | last4 = Teck | first4 = KC. | last5 = Yoke | first5 = PC. | last6 = Goh | first6 = C. | last7 = Balakrishnan | first7 = A. | title = Malignant transformation of keratocystic odontogenic tumor: Two case reports. | journal = Am J Otolaryngol | volume = 34 | issue = 4 | pages = 357-61 | month = | year = | doi = 10.1016/j.amjoto.2013.01.002 | PMID = 23374486 }}</ref> | *Very rarely transforms to a [[squamous cell carinoma]].<ref name=pmid21493332>{{Cite journal | last1 = Lee | first1 = JW. | last2 = Gates | first2 = R. | last3 = Wignall | first3 = A. | title = Squamous cell carcinoma arising from a keratocystic odontogenic tumor. | journal = Otolaryngol Head Neck Surg | volume = 145 | issue = 2 | pages = 356-7 | month = Aug | year = 2011 | doi = 10.1177/0194599811399270 | PMID = 21493332 }}</ref><ref name=pmid23374486>{{Cite journal | last1 = Tan | first1 = B. | last2 = Yan | first2 = TS. | last3 = Shermin | first3 = L. | last4 = Teck | first4 = KC. | last5 = Yoke | first5 = PC. | last6 = Goh | first6 = C. | last7 = Balakrishnan | first7 = A. | title = Malignant transformation of keratocystic odontogenic tumor: Two case reports. | journal = Am J Otolaryngol | volume = 34 | issue = 4 | pages = 357-61 | month = | year = | doi = 10.1016/j.amjoto.2013.01.002 | PMID = 23374486 }}</ref> | ||
===Clinical=== | ===Clinical=== | ||
Revision as of 18:42, 26 July 2013
| Keratocystic odontogenic tumour | |
|---|---|
| Diagnosis in short | |
 Keratocystic odontogenic tumour. H&E stain. | |
|
| |
| LM | Stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane |
| LM DDx | odontogenic cyst (dentigerous cyst), squamous cell carcinoma |
| Site | usually mandible |
|
| |
| Syndromes | nevoid basal cell carcinoma syndrome |
|
| |
| Signs | mass lesion |
| Prevalence | uncommon |
| Clin. DDx | ameloblastoma |
| Keratocystic odontogenic tumour | |
|---|---|
| External resources | |
| EHVSC | 10179 |
| Wikipedia | keratocystic odontogenic tumour |
Keratocystic odontogenic tumour, abbreviated KOT, is an uncommon odontogenic tumour.
It was previously known as odontogenic keratocyst, abbreviated OKC.[1]
General
- May be associated with nevoid basal cell carcinoma syndrome.
- Very rarely transforms to a squamous cell carinoma.[2][3]
Clinical
Features:[4]
- Most common presentation: swelling.
Gross
- Location: usually mandible.
- May mimic ameloblastoma radiologically.
Microscopic
Features: [5]
- Stratified epithelium (resembling squamous epithelium) with:
- "Ribbon-like appearance" - important.
- Typically 8-10 cell layers thick - with relatively uniform thickness.
- Lacks rete ridges.
- Palisaded basal cell layer.
- "Ribbon-like appearance" - important.
- Parakeratosis (keratinized cells with nuclei) - key feature.
- Artefactual separation of epithelium from the basement membrane.
DDx:
- Odontogenic cyst.
- Orthokeratinized odontogenic cyst[6] - usu. dentigerous cyst - has orthokeratosis instead of parakeratosis.
- Orthokeratosis = keratinized cells no nuclei; parakeratosis = keratinized cell with nuclei.
- Orthokeratinized odontogenic cyst[6] - usu. dentigerous cyst - has orthokeratosis instead of parakeratosis.
Images
KOT - intermed. mag. (WC)
KOT - very high mag. (WC)
KOT - poor quality. (WC)
KOT - showing artefactual clefting - poor quality. (WC)
www:
See also
References
- ↑ Madras, J.; Lapointe, H. (Mar 2008). "Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour.". J Can Dent Assoc 74 (2): 165-165h. PMID 18353202.
- ↑ Lee, JW.; Gates, R.; Wignall, A. (Aug 2011). "Squamous cell carcinoma arising from a keratocystic odontogenic tumor.". Otolaryngol Head Neck Surg 145 (2): 356-7. doi:10.1177/0194599811399270. PMID 21493332.
- ↑ Tan, B.; Yan, TS.; Shermin, L.; Teck, KC.; Yoke, PC.; Goh, C.; Balakrishnan, A.. "Malignant transformation of keratocystic odontogenic tumor: Two case reports.". Am J Otolaryngol 34 (4): 357-61. doi:10.1016/j.amjoto.2013.01.002. PMID 23374486.
- ↑ Habibi, A.; Saghravanian, N.; Habibi, M.; Mellati, E.; Habibi, M. (Sep 2007). "Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population.". J Oral Sci 49 (3): 229-35. PMID 17928730.
- ↑ Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.
- ↑ Macdonald-Jankowski, DS. (Dec 2010). "Orthokeratinized odontogenic cyst: a systematic review.". Dentomaxillofac Radiol 39 (8): 455-67. doi:10.1259/dmfr/19728573.
- ↑ URL: http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5. Accessed on: 11 March 2013.