Difference between revisions of "Glioblastoma"
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| Caption = Glioblastoma. [[H&E stain]]. | | Caption = Glioblastoma. [[H&E stain]]. | ||
| Micro = | | Micro = astrocytic differentiation, nuclear atypia, [[necrosis]], microvascular proliferation, +/-pseudopalisading necrosis | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[anaplastic astrocytoma]] | | LMDDx = [[anaplastic astrocytoma]] | ||
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| Prevalence = | | Prevalence = | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = intra-axial | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = very poor | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = [[metastatic]] carcinoma | ||
}} | }} | ||
'''Glioblastoma''' a very common malignant [[brain tumour]] in adults. | '''Glioblastoma''' a very common malignant [[brain tumour]] in adults. | ||
Revision as of 23:32, 23 July 2013
| Glioblastoma | |
|---|---|
| Diagnosis in short | |
 Glioblastoma. H&E stain. | |
|
| |
| LM | astrocytic differentiation, nuclear atypia, necrosis, microvascular proliferation, +/-pseudopalisading necrosis |
| LM DDx | anaplastic astrocytoma |
| IHC | GFAP +ve, IDH-1 -ve/+ve |
| Site | brain, spinal cord |
|
| |
| Radiology | intra-axial |
| Prognosis | very poor |
| Clin. DDx | metastatic carcinoma |
Glioblastoma a very common malignant brain tumour in adults.
It was previously known as glioblastoma multiforme, abbreviated GBM.
General
- Median survival is measured in months.[1]
- Only about 5% can expect to survive more than three years.[2]
Microscopic
Features:
- Astrocytic tumour with:
- Nuclear atypia.
- Necrosis.
- Endothelial proliferation (AKA microvascular proliferation).
- +/-"Pseudopalisading necrosis" - tumour cells lined-up like a picket fence around necrotic areas.
Images
- www:
Extreme nuclear enlargement in a GBM - very high mag. (WC)
GBM juxtaposed with near normal white matter - high mag. (WC)
IHC
- GFAP +ve (cytoplasm).
- IDH-1 -ve.
- +ve if developed from lower grade astrocytoma. (???)
See also
References
- ↑ Jubelirer, SJ.. "A review of the treatment and survival rates of 138 patients with glioblastoma multiforme.". W V Med J 92 (4): 186-90. PMID 8772403.
- ↑ Krex, D.; Klink, B.; Hartmann, C.; von Deimling, A.; Pietsch, T.; Simon, M.; Sabel, M.; Steinbach, JP. et al. (Oct 2007). "Long-term survival with glioblastoma multiforme.". Brain 130 (Pt 10): 2596-606. doi:10.1093/brain/awm204. PMID 17785346.