Difference between revisions of "Mucinous carcinoma"
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*[[Mucinous breast carcinoma]]: > 90% of the tumour.<ref name=pmid22006768>{{Cite journal | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month = | year = | doi = | PMID = 22006768 }}</ref> | *[[Mucinous breast carcinoma]]: > 90% of the tumour.<ref name=pmid22006768>{{Cite journal | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month = | year = | doi = | PMID = 22006768 }}</ref> | ||
**One source suggests: > 50% of the tumour.<ref name=pmid20191033>{{cite journal |author=Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS |title=Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified |journal=J. Korean Med. Sci. |volume=25 |issue=3 |pages=361–8 |year=2010 |month=March |pmid=20191033 |pmc=2826751 |doi=10.3346/jkms.2010.25.3.361 |url=}}</ref> | **One source suggests: > 50% of the tumour.<ref name=pmid20191033>{{cite journal |author=Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS |title=Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified |journal=J. Korean Med. Sci. |volume=25 |issue=3 |pages=361–8 |year=2010 |month=March |pmid=20191033 |pmc=2826751 |doi=10.3346/jkms.2010.25.3.361 |url=}}</ref> | ||
==IHC== | |||
Can be used to suggest a primary site:<ref name=pmid21881489>{{Cite journal | last1 = Chu | first1 = PG. | last2 = Chung | first2 = L. | last3 = Weiss | first3 = LM. | last4 = Lau | first4 = SK. | title = Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1830-6 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e3182299c25 | PMID = 21881489 }}</ref> | |||
*Upper GI tract: CK7 +ve (38/41 cases), CDX2 -ve (4 +ve/41 cases). | |||
*Lower GI tract: CDX2 +ve (42/42 cases), CK20 +ve (41/42 cases), CK7 -ve (8 +ve/42 cases) positive cases usu. in rectum/anus. | |||
*Breast: CK7 +ve (18/18 cases), ER +ve (16/18 cases). | |||
*Lung: CK7 +ve (16/16 cases). | |||
*Gynecologic: CK7 +ve (25/27). | |||
==See also== | ==See also== | ||
Revision as of 14:57, 10 April 2013
Mucinous carcinoma, also mucinous adenocarcinoma, is an epithelial neoplasm that produces mucin. Mucinous carcinoma can arise in a number of sites.
General
Prognostic significance dependent on the primary site:
- Breast mucinous carcinoma has a better prognosis.
- Colorectal mucinous carcinoma has a worse prognosis.[1]
Specific sites
Gross
- Gelatinous-like material.
- May have a consistency similar to Jello.
Image:
- Mucinous adenocarcinoma of the lung (flickr.com).
- Ovarian mucinous cystadenocarcinoma (flickr.com/euthman).
Microscopic
Features:
- Mucin - amphormous whispy or cream material.
- Cytologically atypical cells within the mucin.
- +/-Tumour without mucin.
- Maximum amount acceptable depends on the primary site (see proportion of mucin section below).
Note:
- Mucin alone -- should prompt a search for atypical cells, i.e. levels should be done.
DDx:
- Benign mucocele.
- Mucin extravasation - no malignant cells present.
- Adenoma with pseudoinvasion (pseudocarcinoma).[2]
- Adenocarcinoma with mucinous features - see proportion of mucin section.
Images:
- Colonic mucinous adenocarcinoma - low mag. (WC).
- Mucinous tumours of the ovary - several images (flickr.com).
Proportion of mucin
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
- Mucinous prostate carcinoma: > 25% of the tumour.[3]
- Mucinous colorectal carcinoma: > 50% of the tumour.[4]
- Mucinous gastric carcinoma: > 50% of the tumour.
- Mucinous breast carcinoma: > 90% of the tumour.[5]
- One source suggests: > 50% of the tumour.[6]
IHC
Can be used to suggest a primary site:[7]
- Upper GI tract: CK7 +ve (38/41 cases), CDX2 -ve (4 +ve/41 cases).
- Lower GI tract: CDX2 +ve (42/42 cases), CK20 +ve (41/42 cases), CK7 -ve (8 +ve/42 cases) positive cases usu. in rectum/anus.
- Breast: CK7 +ve (18/18 cases), ER +ve (16/18 cases).
- Lung: CK7 +ve (16/16 cases).
- Gynecologic: CK7 +ve (25/27).
See also
References
- ↑ Hyngstrom, JR.; Hu, CY.; Xing, Y.; You, YN.; Feig, BW.; Skibber, JM.; Rodriguez-Bigas, MA.; Cormier, JN. et al. (Apr 2012). "Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base.". Ann Surg Oncol. doi:10.1245/s10434-012-2321-7. PMID 22476818.
- ↑ Odze, Robert D.; Goldblum, John R. (2009). Surgical pathology of the GI tract, liver, biliary tract and pancreas (2nd ed.). Saunders. pp. 512. ISBN 978-1416040590.
- ↑ Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
- ↑ Tozawa E, Ajioka Y, Watanabe H, et al. (2007). "Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity?". Pathol. Res. Pract. 203 (8): 567–74. doi:10.1016/j.prp.2007.04.013. PMID 17679024.
- ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
- ↑ Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS (March 2010). "Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified". J. Korean Med. Sci. 25 (3): 361–8. doi:10.3346/jkms.2010.25.3.361. PMC 2826751. PMID 20191033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826751/.
- ↑ Chu, PG.; Chung, L.; Weiss, LM.; Lau, SK. (Dec 2011). "Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases.". Am J Surg Pathol 35 (12): 1830-6. doi:10.1097/PAS.0b013e3182299c25. PMID 21881489.