Difference between revisions of "Adrenal gland"
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==Benign== | ==Benign== | ||
===Spironolactone bodies=== | |||
Features:<ref>{{cite journal |author=Kovacs K, Horvath E, Singer W |title=Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex |journal=J. Clin. Pathol. |volume=26 |issue=12 |pages=949-57 |year=1973 |month=December |pmid=4131694 |pmc=477936 |doi= |url=http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=4131694}}</ref> | |||
*Location: zona glomerulosa (where aldosterone is produced). | |||
*Appearance: eosinophilic spherical laminated whorls. | |||
*Etiology: long-term use of spironolactone. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Spironolactone_bodies_high_mag.jpg SB - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Spironolactone_bodies.png SB (circled) - cropped high mag. (WC)]. | |||
==Adenomas== | ==Adenomas== | ||
Revision as of 13:13, 28 September 2010
Adrenal gland is a little organ that hangs-out above the kidney. Pathologists rarely see it. It uncommonly is affected by tumours.
Anatomy & histology
Histology
Composed for cortex and medulla.
- Cortex has three layers - Mnemonic: GFR (from superficial to deep):
- Zona glomerulosa - salt (e.g. aldosterone)
- eosinophilic cytoplasm???
- Normally discontinuous layer.
- Zona fasciculata - sugar (e.g. cortisol)
- Clear cytoplasm - key feature.
- Largest part of the cortex ~ 70%.
- Cells in cords/nests???
- Zona reticularis - steroid (e.g. dehydroepiandrosterone).
- Marked eosinophilia of cytoplasm - key feature.
- Granular/reticular cytoplasm.
- Zona glomerulosa - salt (e.g. aldosterone)
- Medulla - produces NED: norepinephrine, epinephrine, dopamine.
Clinical
Patients getting a bilat. adrenalectomy get pre-treatment with steroids.[1]
Adrenal insuff. may be immediately post-op.[2]
Benign
Spironolactone bodies
Features:[3]
- Location: zona glomerulosa (where aldosterone is produced).
- Appearance: eosinophilic spherical laminated whorls.
- Etiology: long-term use of spironolactone.
Images:
Adenomas
Radiology[4]
- Radiologists are good at identifying adenomas, as they are usually lipid rich and have a characteristic low HU signal.
Treatment is excision if...[5][6]
- Lesions >30 mm.
- Hormonally active.
- Non-incidental finding. (???)
Hyperplasia vs. adenoma
- Hyperplasia is multifocal.[7]
Neoplasms
Benign neoplasms
Adrenal cortical adenoma
Epidemiology
- Often an incidental finding.
Pathologic/clinical:
- May be hormonally active.
Histology
Classic features:
- Well-defined cell borders.
- Clear cytoplasm.
- May have foci of necrosis/degeneration and nuclear atypia.
In aldosterone producing tumours:
- May extend outside of the capsule (should not be diagnosed as adrenal cortical carcinoma.
- No atrophy of non-hyperplastic cortex.
In cortisol producing tumours:
- Atrophy of the non-hyperplastic cortex (due to feedback inhibition from the pituitary gland).
Pheochromocytoma
General
- Considered to be a paraganglioma.[8]
Clinical
- Paroxysms (i.e. episodic) tachycardia, headache, anxiety.
Epidemiology
- Tumour arises from medulla
- Literally means "dusky" (pheo) "colour" (chromo) - dull appearance on gross
Histology
Features:
- Architecture:
- Cell nests, auf deutsch: Zellballen (literally Cell balls).
- Useful for differentiating from ACC.
- Cell nests, auf deutsch: Zellballen (literally Cell balls).
- Nuclei.
- +/-Pleomorphism.
- Nucleoli may be prominent (not signif. prognostically).
- Cellular morphology.
- Polygonal cells.
- Cytoplasm.
- Basophilic, granular.
- Other.
- Haemorrhagic.
Ganglioneuroma
Microscopic
Features:
- Ganglion cells - key feature.
- Large cells with large nucleus.
- Prominent nucleolus.
- Large cells with large nucleus.
- Disordered fibrinous material.
Myelolipoma
Adenomatoid tumour
See: Adenomatoid tumours (uterine tumours).
Malignant neoplasms
Adrenocortical carcinoma (ACC)
Epidemiology:
- Prognosis sucks.
Microscopic
Features:
- Very pleomorphic nuclei.
- High mitotic rate.
- Atypical mitoses.
- Eosinophilic cytoplasm.
Malignant pheochromoctyoma
- Like the description in benign neoplasms.
- Differentiated from benign pheochromocytoma by mets - often aided by radiologic report.
- Features useful for differentiating benign from malignant:[9]
- Marked nuclear atypia.
- Invasion:
- Capsular.
- Vascular.
- Necrosis.
- Cellular monotony.
- Mitoses:
- Rate.
- Atypical mitosis.
Neuroblastoma
Epidemiology
- Usually paediatric population.
Microscopic
Features:
- See: Small round cell tumours.
See also
References
- ↑ URL: http://www3.interscience.wiley.com/cgi-bin/fulltext/119909358/PDFSTART. Accessed on: 21 August 2010.
- ↑ URL: http://ats.ctsnetjournals.org/cgi/content/full/62/5/1516. Accessed on: 21 August 2010.
- ↑ Kovacs K, Horvath E, Singer W (December 1973). "Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex". J. Clin. Pathol. 26 (12): 949-57. PMC 477936. PMID 4131694. http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=4131694.
- ↑ URL: http://emedicine.medscape.com/article/376240-overview.
- ↑ Luton, JP.; Martinez, M.; Coste, J.; Bertherat, J. (Jul 2000). "Outcome in patients with adrenal incidentaloma selected for surgery: an analysis of 88 cases investigated in a single clinical center.". Eur J Endocrinol 143 (1): 111-7. PMID 10870039.
- ↑ Liu, XK.; Liu, XJ.; Dong, X.; Kong, CZ. (Jun 2008). "[Clinical research about treatment for adrenal incidentalomas]". Zhonghua Wai Ke Za Zhi 46 (11): 832-4. PMID 19035218.
- ↑ IAV. 18 February 2009.
- ↑ Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 327. ISBN 978-0443066856.
- ↑ Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 259. ISBN 978-0443066856.