Difference between revisions of "Fibromatoses"
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*[[GIST]]. | *[[GIST]]. | ||
Images: | |||
*[http://www.sarcomaimages.com/index.php?v=Plantar-Fibromatosis Plantar fibromatosis (sarcomaimages.com)]. | *[http://www.sarcomaimages.com/index.php?v=Plantar-Fibromatosis Plantar fibromatosis (sarcomaimages.com)]. | ||
*[http://www.flickr.com/photos/lunarcaustic/5333412517/in/photostream/ Mesenteric fibromatosis (flickr.com)]. | *[http://www.flickr.com/photos/lunarcaustic/5333412517/in/photostream/ Mesenteric fibromatosis (flickr.com)]. | ||
*[http://radiographics.rsna.org/content/29/7/2143/F17.expansion.html Plantar fibromatosis (rsna.org)].<ref name=pmid19926768>{{Cite journal | last1 = Murphey | first1 = MD. | last2 = Ruble | first2 = CM. | last3 = Tyszko | first3 = SM. | last4 = Zbojniewicz | first4 = AM. | last5 = Potter | first5 = BK. | last6 = Miettinen | first6 = M. | title = From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. | journal = Radiographics | volume = 29 | issue = 7 | pages = 2143-73 | month = Nov | year = 2009 | doi = 10.1148/rg.297095138 | PMID = 19926768 }}</ref> | |||
==IHC== | ==IHC== | ||
Revision as of 20:29, 30 January 2013
Fibromatoses are a group of benign stromal lesions that may be seen in pediatric pathology and may or may not be associated with syndromes.
Syndromes associated with fibromatoses
- Familial adenomatous polyposis.[1]
- Hereditary desmoid syndrome.
Types
Superficial
- Palmar (Dupuytren's contracture).
- Plantar.
- Penile (Peyronie's disease).
Deep
- Desmoid-type fibromatosis.
- Others.
Gross
- Firm.
- Infiltrative borders.
Image:
Microscopic
Features:
- Bland spindle cells - typically in fascicles.
- Pale eosinophilic cytoplasm.[2]
- Small thin blood vessels that are parallel to one another.
- Nuclei of blood vessels are typically darker staining than those of the lesion.
DDx:
- Metaplastic carcinoma, e.g. metaplastic breast carcinoma.
- Nodular fasciitis.
- Dermatofibroma.
- GIST.
Images:
- Plantar fibromatosis (sarcomaimages.com).
- Mesenteric fibromatosis (flickr.com).
- Plantar fibromatosis (rsna.org).[3]
IHC
- Beta-catenin +ve.[citation needed]
- CD117 -ve.
Image:
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1092. ISBN 978-1416031215.
- ↑ URL: http://www.histopathology-india.net/Fibromatosis.htm. Accessed on: 18 September 2012.
- ↑ Murphey, MD.; Ruble, CM.; Tyszko, SM.; Zbojniewicz, AM.; Potter, BK.; Miettinen, M. (Nov 2009). "From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation.". Radiographics 29 (7): 2143-73. doi:10.1148/rg.297095138. PMID 19926768.