Difference between revisions of "Mucinous carcinoma"
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'''Mucinous carcinoma''' is an epithelial neoplasm that produces mucin. | '''Mucinous carcinoma''' is an epithelial neoplasm that produces [[mucin]]. Mucinous carcinoma can arise in a number of sites. | ||
Mucinous carcinoma can arise in a number of sites. | |||
==General== | ==General== | ||
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DDx: | DDx: | ||
*Benign [[mucocele]]. | *Benign [[mucocele]]. | ||
*[[Mucin extravasation]] (pseudocarcinoma).<ref name=Ref_Odze512>{{Ref Odze|512}}</ref> | |||
*[[Adenocarcinoma]] with mucinous features. | *[[Adenocarcinoma]] with mucinous features. | ||
Revision as of 19:20, 13 August 2012
Mucinous carcinoma is an epithelial neoplasm that produces mucin. Mucinous carcinoma can arise in a number of sites.
General
Prognostic significance dependent on the primary site:
- Breast mucinous carcinoma has a better prognosis.
- Colorectal mucinous carcinoma has a worse prognosis.[1]
Microscopic
Features:
- Mucin - amphormous whispy or cream material.
- Cytologically atypical cells within the mucin.
- +/-Tumour without mucin.
- Maximum amount acceptable depends on the primary site (see proportion of mucin section below).
Note:
- Mucin alone -- should prompt a search for atypical cells, i.e. levels should be done.
DDx:
- Benign mucocele.
- Mucin extravasation (pseudocarcinoma).[2]
- Adenocarcinoma with mucinous features.
Proportion of mucin
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
- Mucinous prostate carcinoma: > 25% of the tumour.[3]
- Mucinous colorectal carcinoma: > 50% of the tumour.[4]
- Mucinous gastric carcinoma: > 50% of the tumour.
- Mucinous breast carcinoma: > 90% of the tumour.[5]
- One source suggests: > 50% of the tumour.[6]
See also
References
- ↑ PMID 22476818.
- ↑ Odze, Robert D.; Goldblum, John R. (2009). Surgical pathology of the GI tract, liver, biliary tract and pancreas (2nd ed.). Saunders. pp. 512. ISBN 978-1416040590.
- ↑ Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
- ↑ Tozawa E, Ajioka Y, Watanabe H, et al. (2007). "Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity?". Pathol. Res. Pract. 203 (8): 567–74. doi:10.1016/j.prp.2007.04.013. PMID 17679024.
- ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
- ↑ Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS (March 2010). "Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified". J. Korean Med. Sci. 25 (3): 361–8. doi:10.3346/jkms.2010.25.3.361. PMC 2826751. PMID 20191033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826751/.