Difference between revisions of "Mucinous carcinoma"
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Mucinous carcinoma can arise in a number of sites. | Mucinous carcinoma can arise in a number of sites. | ||
==General== | |||
*Often have a better prognosis that tumours without mucinous differentiation. | |||
==Microscopic== | |||
Features: | |||
#Mucin - amphormous whispy or cream material. | |||
#Cytologically atypical cells within the mucin. | |||
#+/-Tumour without mucin. | |||
#*Maximum amount acceptable depends on the primary site (see ''proportion of mucin'' section below). | |||
Note: | |||
*Mucin alone -- should prompt a search for atypical cells, i.e. [[levels]] should be done. | |||
DDx: | |||
*Benign [[mucocele]]. | |||
*[[Adenocarcinoma]] with mucinous features. | |||
===Proportion of mucin=== | |||
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site: | The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site: | ||
*[[Mucinous prostate carcinoma]]: > 25% of the tumour.<ref name=pmid14976541>{{cite journal |author=Grignon DJ |title=Unusual subtypes of prostate cancer |journal=Mod. Pathol. |volume=17 |issue=3 |pages=316–27 |year=2004 |month=March |pmid=14976541 |doi=10.1038/modpathol.3800052 |url=}}</ref> | *[[Mucinous prostate carcinoma]]: > 25% of the tumour.<ref name=pmid14976541>{{cite journal |author=Grignon DJ |title=Unusual subtypes of prostate cancer |journal=Mod. Pathol. |volume=17 |issue=3 |pages=316–27 |year=2004 |month=March |pmid=14976541 |doi=10.1038/modpathol.3800052 |url=}}</ref> | ||
Revision as of 12:55, 13 August 2012
Mucinous carcinoma is an epithelial neoplasm that produces mucin.
Mucinous carcinoma can arise in a number of sites.
General
- Often have a better prognosis that tumours without mucinous differentiation.
Microscopic
Features:
- Mucin - amphormous whispy or cream material.
- Cytologically atypical cells within the mucin.
- +/-Tumour without mucin.
- Maximum amount acceptable depends on the primary site (see proportion of mucin section below).
Note:
- Mucin alone -- should prompt a search for atypical cells, i.e. levels should be done.
DDx:
- Benign mucocele.
- Adenocarcinoma with mucinous features.
Proportion of mucin
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
- Mucinous prostate carcinoma: > 25% of the tumour.[1]
- Mucinous colorectal carcinoma: > 50% of the tumour.[2]
- Mucinous gastric carcinoma: > 50% of the tumour.
- Mucinous breast carcinoma: > 90% of the tumour.[3]
- One source suggests: > 50% of the tumour.[4]
See also
References
- ↑ Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
- ↑ Tozawa E, Ajioka Y, Watanabe H, et al. (2007). "Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity?". Pathol. Res. Pract. 203 (8): 567–74. doi:10.1016/j.prp.2007.04.013. PMID 17679024.
- ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
- ↑ Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS (March 2010). "Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified". J. Korean Med. Sci. 25 (3): 361–8. doi:10.3346/jkms.2010.25.3.361. PMC 2826751. PMID 20191033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826751/.