Difference between revisions of "Sinonasal undifferentiated carcinoma"

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#redirect [[Head_and_neck_pathology#Sinonasal_undifferentiated_carcinoma]]
'''Sinonasal undifferentiated carcinoma''', abbreviated '''SNUC''', is a rare epithelial malignancy of the [[head and neck pathology|head and neck]].


==General==
*Aggressive/poor prognosis.
**In the past, survival was measured in months.<ref name=pmid17170968>{{Cite journal  | last1 = Pitman | first1 = KT. | last2 = Costantino | first2 = PD. | last3 = Lassen | first3 = LF. | title = Sinonasal undifferentiated carcinoma: current trends in treatment. | journal = Skull Base Surg | volume = 5 | issue = 4 | pages = 269-72 | month =  | year = 1995 | doi =  | PMID = 17170968 | PMC = 1656535 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1656535/ }}</ref>
**With (aggressive) combined modality treatment, the overall five-year survival is approximately 75%.<ref name=pmid22476411>{{Cite journal  | last1 = Al-Mamgani | first1 = A. | last2 = van Rooij | first2 = P. | last3 = Mehilal | first3 = R. | last4 = Tans | first4 = L. | last5 = Levendag | first5 = PC. | title = Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. | journal = Eur Arch Otorhinolaryngol | volume =  | issue =  | pages =  | month = Apr | year = 2012 | doi = 10.1007/s00405-012-2008-5 | PMID = 22476411 }}</ref>
==Microscopic==
Features:<ref name=Ref_WMSP38>{{Ref WMSP|38}}</ref>
*Architecture: nested, trabecular or lobular.
*Distinct cellular borders.
*Small-to-moderate cytoplasm.
*+/-Distinct nucleoli.
*Tumour cell size variable (small to large).
Note:
*Glandular and squamous differentiation are absent by definition.<ref name=pmid11904342/>
Images:
*www:
**[http://www.nature.com/modpathol/journal/v15/n3/fig_tab/3880522f7.html SNUC (nature.com)].<ref name=pmid11904342>{{Cite journal  | last1 = Mills | first1 = SE. | title = Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. | journal = Mod Pathol | volume = 15 | issue = 3 | pages = 264-78 | month = Mar | year = 2002 | doi = 10.1038/modpathol.3880522 | PMID = 11904342 | URL = http://dx.doi.org/10.1038/modpathol.3880522 }}</ref>
**[http://www.pathologypics.com/PictView.aspx?ID=244 SNUC (pathologypics.com)].
**[http://www.pathologypics.com/PictView.aspx?ID=249 SNUC (pathologypics.com)].
*[[WC]]:
**[http://commons.wikimedia.org/wiki/File:Sinonasal_undifferentiated_carcinoma_-_low_mag.jpg SNUC - low mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Sinonasal_undifferentiated_carcinoma_-_high_mag.jpg SNUC - high mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Sinonasal_undifferentiated_carcinoma_-_very_high_mag.jpg SNUC - very high mag. (WC)].
==IHC==
Features:<ref name=Ref_WMSP38>{{Ref WMSP|38}}</ref>
*Pankeratin +ve.
*[[EMA]] +ve.
*CK7 +ve.
*CK5/6 -ve.
Others:
*NSE +ve/-ve.
*Chromogranin A -ve.
*Synaptophysin -ve.
*p63 +ve/-ve.<ref name=pmid21805120>{{Cite journal  | last1 = Wadsworth | first1 = B. | last2 = Bumpous | first2 = JM. | last3 = Martin | first3 = AW. | last4 = Nowacki | first4 = MR. | last5 = Jenson | first5 = AB. | last6 = Farghaly | first6 = H. | title = Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). | journal = Head Neck Pathol | volume = 5 | issue = 4 | pages = 349-54 | month = Dec | year = 2011 | doi = 10.1007/s12105-011-0285-8 | PMID = 21805120 | PMC = 3210220 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210220/ }}</ref>
==See also==
*[[Head and neck pathology]].
*[[Squamous cell carcinoma of the head and neck]].
==References==
{{Reflist|2}}
[[Category:Head and neck pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 05:02, 27 July 2014

Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare epithelial malignancy of the head and neck.

General

  • Aggressive/poor prognosis.
    • In the past, survival was measured in months.[1]
    • With (aggressive) combined modality treatment, the overall five-year survival is approximately 75%.[2]

Microscopic

Features:[3]

  • Architecture: nested, trabecular or lobular.
  • Distinct cellular borders.
  • Small-to-moderate cytoplasm.
  • +/-Distinct nucleoli.
  • Tumour cell size variable (small to large).

Note:

  • Glandular and squamous differentiation are absent by definition.[4]

Images:

IHC

Features:[3]

  • Pankeratin +ve.
  • EMA +ve.
  • CK7 +ve.
  • CK5/6 -ve.

Others:

  • NSE +ve/-ve.
  • Chromogranin A -ve.
  • Synaptophysin -ve.
  • p63 +ve/-ve.[5]

See also

References

  1. ↑ Pitman, KT.; Costantino, PD.; Lassen, LF. (1995). "Sinonasal undifferentiated carcinoma: current trends in treatment.". Skull Base Surg 5 (4): 269-72. PMC 1656535. PMID 17170968. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1656535/.
  2. ↑ Al-Mamgani, A.; van Rooij, P.; Mehilal, R.; Tans, L.; Levendag, PC. (Apr 2012). "Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature.". Eur Arch Otorhinolaryngol. doi:10.1007/s00405-012-2008-5. PMID 22476411.
  3. ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 38. ISBN 978-0781765275.
  4. ↑ 4.0 4.1 Mills, SE. (Mar 2002). "Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.". Mod Pathol 15 (3): 264-78. doi:10.1038/modpathol.3880522. PMID 11904342.
  5. ↑ Wadsworth, B.; Bumpous, JM.; Martin, AW.; Nowacki, MR.; Jenson, AB.; Farghaly, H. (Dec 2011). "Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV).". Head Neck Pathol 5 (4): 349-54. doi:10.1007/s12105-011-0285-8. PMC 3210220. PMID 21805120. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210220/.
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