Difference between revisions of "Hypersensitivity"
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'''Hypersensitivity''' is a thingy one may get | '''Hypersensitivity''' is an inappropriate immune system response. It is a thingy one may get quizzed on. | ||
==Gell & Coombs classification== | |||
Gell & Coombs, in the 1960s, came-up with a classification that has endured. | |||
{|Class="wikitable" | {|Class="wikitable" | ||
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==See also== | ==See also== | ||
*[[Hypersensitivity pneumonitis]]. | *[[Hypersensitivity pneumonitis]]. | ||
*[[Common variable immunodeficiency]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Stuff]] | [[Category:Stuff]] | ||
Revision as of 19:45, 13 November 2011
Hypersensitivity is an inappropriate immune system response. It is a thingy one may get quizzed on.
Gell & Coombs classification
Gell & Coombs, in the 1960s, came-up with a classification that has endured.
| Type (I-IV) | Formal name[1] | Name | Example | Mediator | Pathology |
|---|---|---|---|---|---|
| I | Immediate h. | Allergic h. | anaphylaxis, (atopic) bronchial asthma, allergies | antibodies (IgE) | mast cells, inflammation (esp. eosinophils), edema |
| II | Antibody mediated h. | Cytotoxic antibody dependent h. | Goodpasture syndrome, Graves disease | antibodies (IgG, IgM) | (antibody-mediated) phagocytosis & lysis |
| III | Immune complex mediated h. | Immune complex mediated h. | systemic lupus erythematosus, hypersensitivity pneumonitis,[2] rheumatoid arthritis | antigen-antibody complex | inflammation, vasculitis with fibrinoid necrosis |
| IV | Cell-mediated h. | Delayed-type hypersensitivity | tuberculosis, contact dermatitis, chronic transplant rejection, inflammatory bowel disease | activated T cells | perivascular inflammation, granulomas |
Memory device ACID:[3]
- Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
- ↑ Kaltreider, HB. (Nov 1993). "Hypersensitivity pneumonitis.". West J Med 159 (5): 570-8. PMID 8279154. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed.
- ↑ URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.