Difference between revisions of "Hyalinizing clear cell carcinoma"

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#redirect [[Salivary glands#Hyalinizing clear cell carcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Hyalinizing_clear_cell_carcinoma_-_very_high_mag.jpg
| Width      =
| Caption    = Hyalinizing clear cell carcinoma. [[H&E stain]].
| Micro      = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma
| Subtypes  =
| LMDDx      =
| Stains    = PAS +ve
| IHC        = AE1/AE3 +ve, EMA +ve.
| EM        =
| Molecular  = t(12;22) -- EWSR1/ATF1
| IF        =
| Gross      =
| Grossing  =
| Site      = usu. palate or tongue
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
}}
'''Hyalinizing clear cell carcinoma''', abbreviated ''HCCC'', is a rare malignant [[salivary gland]] tumour with a good prognosis.
 
==General==
*Rare.
*Good prognosis.<ref name=pmid21393908>{{Cite journal  | last1 = Masilamani | first1 = S. | last2 = Rao | first2 = S. | last3 = Chirakkal | first3 = P. | last4 = Kumar | first4 = AR. | title = Hyalinizing clear cell carcinoma of the base of tongue: a distinct and rare entity. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 167-9 | month =  | year =  | doi = 10.4103/0377-4929.77393 | PMID = 21393908 }}</ref>
*Typically palate or tongue.<ref name=pmid21669357>{{Cite journal  | last1 = Kauzman | first1 = A. | last2 = Tabet | first2 = JC. | last3 = Stiharu | first3 = TI. | title = Hyalinizing clear cell carcinoma: a case report and review of the literature. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 112 | issue = 1 | pages = e26-34 | month = Jul | year = 2011 | doi = 10.1016/j.tripleo.2011.02.041 | PMID = 21669357 }}</ref>
 
==Microscopic==
Features:<ref name=pmid20596970>{{Cite journal  | last1 = O'Sullivan-Mejia | first1 = ED. | last2 = Massey | first2 = HD. | last3 = Faquin | first3 = WC. | last4 = Powers | first4 = CN. | title = Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. | journal = Head Neck Pathol | volume = 3 | issue = 3 | pages = 179-85 | month = Sep | year = 2009 | doi = 10.1007/s12105-009-0124-3 | PMID = 20596970 }}</ref>
*Groups of cells with abundant clear cytoplasm.
**Arranged in cords, trabeculae or clusters.
**Minimal [[nuclear pleomorphism]].<ref name=pmid7506496/>
*Hyalinized stroma.
 
Notes:
*Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal  | last1 = Milchgrub | first1 = S. | last2 = Gnepp | first2 = DR. | last3 = Vuitch | first3 = F. | last4 = Delgado | first4 = R. | last5 = Albores-Saavedra | first5 = J. | title = Hyalinizing clear cell carcinoma of salivary gland. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 74-82 | month = Jan | year = 1994 | doi =  | PMID = 7506496 }}</ref>
*Low mitotic rate.
 
DDx:
*[[Mucoepidermoid carcinoma]], clear cell variant.
*[[Acinic cell carcinoma]], clear cell variant.
*Metastatic [[clear cell renal cell carcinoma]].
**Classically have hemorrhage & [[necrosis]].
*[[Epithelial-myoepithelial carcinoma]].
 
===Images===
<gallery>
Image:Hyalinizing_clear_cell_carcinoma_-_intermed_mag.jpg | HCCC - intermed. mag. (WC/Nephron)
Image:Hyalinizing_clear_cell_carcinoma_-_high_mag.jpg | HCCC - high mag. (WC/Nephron)
Image:Hyalinizing_clear_cell_carcinoma_-_very_high_mag.jpg | HCCC - very high mag. (WC/Nephron)
</gallery>
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/>
==Stains==
*PAS +ve.
 
==IHC==
*AE1/AE3 +ve.
*EMA +ve.<ref name=pmid7506496/>
 
Others:
*Desmin -ve.
*SMA -ve.<ref name=pmid7506496/>
*S-100 -ve.<ref name=pmid7506496>{{Cite journal  | last1 = Milchgrub | first1 = S. | last2 = Gnepp | first2 = DR. | last3 = Vuitch | first3 = F. | last4 = Delgado | first4 = R. | last5 = Albores-Saavedra | first5 = J. | title = Hyalinizing clear cell carcinoma of salivary gland. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 74-82 | month = Jan | year = 1994 | doi =  | PMID = 7506496 }}</ref>
 
==Molecular==
Recurrent [[translocation]]:<ref name=pmid21484932>{{Cite journal  | last1 = Antonescu | first1 = CR. | last2 = Katabi | first2 = N. | last3 = Zhang | first3 = L. | last4 = Sung | first4 = YS. | last5 = Seethala | first5 = RR. | last6 = Jordan | first6 = RC. | last7 = Perez-Ordoñez | first7 = B. | last8 = Have | first8 = C. | last9 = Asa | first9 = SL. | title = EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. | journal = Genes Chromosomes Cancer | volume = 50 | issue = 7 | pages = 559-70 | month = Jul | year = 2011 | doi = 10.1002/gcc.20881 | PMID = 21484932 }}</ref>
*t(12;22) -- EWSR1/ATF1.
**Same translocation as in ''[[clear cell sarcoma]]''.
 
==See also==
*[[Salivary glands]].
*[[Head and neck pathology]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Salivary gland]]
[[Category:Head and neck pathology]]

Revision as of 13:34, 30 July 2013

Hyalinizing clear cell carcinoma
Diagnosis in short

Hyalinizing clear cell carcinoma. H&E stain.
LM cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal nuclear pleomorphism; hyalinized stroma
Stains PAS +ve
IHC AE1/AE3 +ve, EMA +ve.
Molecular t(12;22) -- EWSR1/ATF1
Site usu. palate or tongue
Prevalence rare
Prognosis good

Hyalinizing clear cell carcinoma, abbreviated HCCC, is a rare malignant salivary gland tumour with a good prognosis.

General

  • Rare.
  • Good prognosis.[1]
  • Typically palate or tongue.[2]

Microscopic

Features:[3]

  • Groups of cells with abundant clear cytoplasm.
  • Hyalinized stroma.

Notes:

  • Clear cytoplasm due to glycogen.[4]
  • Low mitotic rate.

DDx:

Images

  • HCCC - intermed. mag. (WC/Nephron)

  • HCCC - high mag. (WC/Nephron)

  • HCCC - very high mag. (WC/Nephron)

www:

Stains

  • PAS +ve.

IHC

  • AE1/AE3 +ve.
  • EMA +ve.[4]

Others:

  • Desmin -ve.
  • SMA -ve.[4]
  • S-100 -ve.[4]

Molecular

Recurrent translocation:[5]

See also

References

  1. ↑ Masilamani, S.; Rao, S.; Chirakkal, P.; Kumar, AR.. "Hyalinizing clear cell carcinoma of the base of tongue: a distinct and rare entity.". Indian J Pathol Microbiol 54 (1): 167-9. doi:10.4103/0377-4929.77393. PMID 21393908.
  2. ↑ Kauzman, A.; Tabet, JC.; Stiharu, TI. (Jul 2011). "Hyalinizing clear cell carcinoma: a case report and review of the literature.". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112 (1): e26-34. doi:10.1016/j.tripleo.2011.02.041. PMID 21669357.
  3. ↑ 3.0 3.1 O'Sullivan-Mejia, ED.; Massey, HD.; Faquin, WC.; Powers, CN. (Sep 2009). "Hyalinizing clear cell carcinoma: report of eight cases and a review of literature.". Head Neck Pathol 3 (3): 179-85. doi:10.1007/s12105-009-0124-3. PMID 20596970.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Milchgrub, S.; Gnepp, DR.; Vuitch, F.; Delgado, R.; Albores-Saavedra, J. (Jan 1994). "Hyalinizing clear cell carcinoma of salivary gland.". Am J Surg Pathol 18 (1): 74-82. PMID 7506496.
  5. ↑ Antonescu, CR.; Katabi, N.; Zhang, L.; Sung, YS.; Seethala, RR.; Jordan, RC.; Perez-Ordoñez, B.; Have, C. et al. (Jul 2011). "EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland.". Genes Chromosomes Cancer 50 (7): 559-70. doi:10.1002/gcc.20881. PMID 21484932.
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