Difference between revisions of "Salivary duct carcinoma"

From Libre Pathology
Jump to navigation Jump to search
(+cat.)
(split out)
Line 1: Line 1:
#redirect [[Salivary_glands#Salivary_duct_carcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Micro      =
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      =
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
}}
'''Salivary duct carcinoma''', abbreviated '''SDC''', is a rare [[salivary gland]] tumour that typically has an aggressive course.
 
==General==
*Malignant counterpart of ''salivary duct adenoma''.
*Male:female ~= 4:1.
*Dismal prognosis.<ref name=pmid21393874>{{Cite journal  | last1 = Rajesh | first1 = NG. | last2 = Prayaga | first2 = AK. | last3 = Sundaram | first3 = C. | title = Salivary duct carcinoma: correlation of morphologic features by fine needle aspiration cytology and histopathology. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 37-41 | month =  | year =  | doi = 10.4103/0377-4929.77321 | PMID = 21393874 | url = http://www.ijpmonline.org/text.asp?2011/54/1/37/77321 }}</ref>
*Typically >50 years old.
*Mostly in the parotid.
 
==Microscopic==
Features - resembles ductal breast carcinoma:<ref name=pmid21393874/>
*Architecture: sheets, nests, cords, cribriform, micropapillary.
*Neoplastic cells line-up around cystic spaces "Roman bridges".
*Nuclear atypia (variation in size, shape, staining).
*Apocrine snouts - pseudopod-like/lollipop-like undulations of the cell membrane.
*Decapitation secretions - apocrine snouts (membrane bound blobs of cytoplasm) that have separated from its mother cell.
 
Notes:
*Similar to ductal breast carcinoma - '''key to remember'''.
 
DDx:
*[[Carcinoma ex pleomorphic adenoma]] with SDC component.
 
===Images===
<gallery>
Image:Salivary duct carcinoma - very low mag.jpg | SDC - very low mag. (WC/Nephron)
Image:Salivary_duct_carcinoma_-_low_mag.jpg | SDC - low mag. (WC/Nephron)
Image:Salivary duct carcinoma - intermed mag.jpg | SDC - intermed. mag. (WC/Nephron)
Image:Salivary_duct_carcinoma_-_high_mag.jpg | SDC - high mag. (WC/Nephron)
Image:Salivary duct carcinoma - very high mag.jpg | SDC - very high mag. (WC/Nephron)
</gallery>
<gallery>
Image:Salivary_duct_carcinoma_-a-_low_mag.jpg | SDC - low mag. (WC/Nephron)
Image:Salivary duct carcinoma -a- intermed mag.jpg | SDC - intermed. mag. (WC/Nephron)
</gallery>
www:
*[http://www.webpathology.com/image.asp?case=122&n=2 Salivary duct carcinoma (webpathology.com)].
 
===Subtypes===
*Conventional.
*Mucinous - worse prognosis; opposite of what would one expect from the outcomes in [[breast cancer]].
*Micropapillary - assoc. with a poor prognosis.
*Sarcomatoid/spindle cell.
 
==IHC==
*LMWK, EMA, CK7, CK19 +ve.
*p63 -ve.
*Androgen receptor +ve.
*BRST2 (GCDFP-15) +ve.
*HER2 +ve ~21%; use of [[trastuzumab]] (Herceptin) not systematically studied.
 
Curiosity:
*PSA +/-.
*PSAP +/-.
*ER-beta +ve.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf]. Accessed on: 3 April 2012.</ref>
*ER-alpha -ve (the common ''ER'' stain).
 
==See also==
*[[Salivary glands]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Salivary gland]]

Revision as of 09:26, 29 July 2013

Salivary duct carcinoma
Diagnosis in short

Salivary duct carcinoma, abbreviated SDC, is a rare salivary gland tumour that typically has an aggressive course.

General

  • Malignant counterpart of salivary duct adenoma.
  • Male:female ~= 4:1.
  • Dismal prognosis.[1]
  • Typically >50 years old.
  • Mostly in the parotid.

Microscopic

Features - resembles ductal breast carcinoma:[1]

  • Architecture: sheets, nests, cords, cribriform, micropapillary.
  • Neoplastic cells line-up around cystic spaces "Roman bridges".
  • Nuclear atypia (variation in size, shape, staining).
  • Apocrine snouts - pseudopod-like/lollipop-like undulations of the cell membrane.
  • Decapitation secretions - apocrine snouts (membrane bound blobs of cytoplasm) that have separated from its mother cell.

Notes:

  • Similar to ductal breast carcinoma - key to remember.

DDx:

Images

  • SDC - very low mag. (WC/Nephron)

  • SDC - low mag. (WC/Nephron)

  • SDC - intermed. mag. (WC/Nephron)

  • SDC - high mag. (WC/Nephron)

  • SDC - very high mag. (WC/Nephron)

  • SDC - low mag. (WC/Nephron)

  • SDC - intermed. mag. (WC/Nephron)

www:

Subtypes

  • Conventional.
  • Mucinous - worse prognosis; opposite of what would one expect from the outcomes in breast cancer.
  • Micropapillary - assoc. with a poor prognosis.
  • Sarcomatoid/spindle cell.

IHC

  • LMWK, EMA, CK7, CK19 +ve.
  • p63 -ve.
  • Androgen receptor +ve.
  • BRST2 (GCDFP-15) +ve.
  • HER2 +ve ~21%; use of trastuzumab (Herceptin) not systematically studied.

Curiosity:

  • PSA +/-.
  • PSAP +/-.
  • ER-beta +ve.[2]
  • ER-alpha -ve (the common ER stain).

See also

References

  1. ↑ 1.0 1.1 Rajesh, NG.; Prayaga, AK.; Sundaram, C.. "Salivary duct carcinoma: correlation of morphologic features by fine needle aspiration cytology and histopathology.". Indian J Pathol Microbiol 54 (1): 37-41. doi:10.4103/0377-4929.77321. PMID 21393874. http://www.ijpmonline.org/text.asp?2011/54/1/37/77321.
  2. ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf. Accessed on: 3 April 2012.
Retrieved from "https://librepathology.org/w/index.php?title=Salivary_duct_carcinoma&oldid=23383"