Difference between revisions of "Chondroblastoma"

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#redirect [[Chondro-osseous tumours#Chondroblastoma]]
'''Chondroblastoma''' is a benign [[chondro-osseous tumour]] that afflicts the young (growth plates open).
 
==General==
*Growth plate lesion.
*Sclerotic margin.
*"Young" = growth plates open.
*Typically painful.<ref name=Ref_PCPBoD8_625>{{Ref PCPBoD8|625}}</ref>
 
==Gross==
*Well-defined lesion.
 
===Image===
*[http://www.flickr.com/photos/35441329@N05/4052875138/in/set-72157622681280610 Chondroblastoma (flickr.com/humpath)].
 
==Microscopic==
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref>
*Abundant extracellular material - pink on [[H&E stain]] - looks vaguely like cartilage.
*Chondroblasts:
**Nuclear morphology variable: ovoid, folded or grooved.
**Moderate-abundant eosinophilic cytoplasm.
*+/-Calcification surrounds the cell nests ("chickenwire" appearance) - '''classic feature'''.
**Cell nests have a thin pale blue rimming.
*+/-[[Giant cells]].
**May lead to confusion with ''[[giant cell tumour of bone]]''.
 
DDx:
*[[Giant cell tumour of bone]].
*[[Chondroma]].
*Well-differentiated [[chondrosarcoma]].
 
===Images===
<gallery>
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC)
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC)
</gallery>
www:
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://path.upmc.edu/cases/case494/images/fig2a.jpg Chondroblastoma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case494.html http://path.upmc.edu/cases/case494.html]. Accessed on: 24 January 2012.</ref>
 
==IHC==
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref>
*S100 +ve.
*Vimentin +ve.<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
 
==See also==
*[[Chondro-osseous tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Chondro-osseous tumours]]

Revision as of 00:21, 1 April 2014

Chondroblastoma is a benign chondro-osseous tumour that afflicts the young (growth plates open).

General

  • Growth plate lesion.
  • Sclerotic margin.
  • "Young" = growth plates open.
  • Typically painful.[1]

Gross

  • Well-defined lesion.

Image

Microscopic

Features:[2]

  • Abundant extracellular material - pink on H&E stain - looks vaguely like cartilage.
  • Chondroblasts:
    • Nuclear morphology variable: ovoid, folded or grooved.
    • Moderate-abundant eosinophilic cytoplasm.
  • +/-Calcification surrounds the cell nests ("chickenwire" appearance) - classic feature.
    • Cell nests have a thin pale blue rimming.
  • +/-Giant cells.

DDx:

Images

  • Chondroblastoma - intermed. mag. (WC)

  • Chondroblastoma - very high mag. (WC)

www:

IHC

Features:[2]

  • S100 +ve.
  • Vimentin +ve.[3]

See also

References

  1. ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 625. ISBN 978-1416054542.
  2. ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 642. ISBN 978-0781765275.
  3. ↑ 3.0 3.1 3.2 URL: http://emedicine.medscape.com/article/1254949-diagnosis. Accessed on: 31 December 2010.
  4. ↑ URL: http://path.upmc.edu/cases/case494.html. Accessed on: 24 January 2012.
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