Difference between revisions of "Panniculitis"
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==Erythema nodosum== | ==Erythema nodosum== | ||
*Most common from of panniculitis.<ref name=pmid17375516>{{Cite journal | last1 = Schwartz | first1 = RA. | last2 = Nervi | first2 = SJ. | title = Erythema nodosum: a sign of systemic disease. | journal = Am Fam Physician | volume = 75 | issue = 5 | pages = 695-700 | month = Mar | year = 2007 | doi = | PMID = 17375516 | URL = http://www.aafp.org/afp/2007/0301/p695.html }}</ref> | *Most common from of panniculitis.<ref name=pmid17375516>{{Cite journal | last1 = Schwartz | first1 = RA. | last2 = Nervi | first2 = SJ. | title = Erythema nodosum: a sign of systemic disease. | journal = Am Fam Physician | volume = 75 | issue = 5 | pages = 695-700 | month = Mar | year = 2007 | doi = | PMID = 17375516 | URL = http://www.aafp.org/afp/2007/0301/p695.html }}</ref> | ||
*Classically on the shins - resolves without scarring.<ref name=medscape_en>URL: [http://www.medscape.com/viewarticle/440356_8 http://www.medscape.com/viewarticle/440356_8]. Accessed on: 11 September 2011.</ref> | |||
Causes - mnemonic ''NODOSUM'':<ref name=pmid17375516/> | Causes - mnemonic ''NODOSUM'':<ref name=pmid17375516/> | ||
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===General=== | ===General=== | ||
Features:<ref name=Ref_PBoD8_1199>{{Ref PBoD8|1199}}</ref> | Features:<ref name=Ref_PBoD8_1199>{{Ref PBoD8|1199}}</ref> | ||
* | *Uncommon. | ||
*Etiology: unknown. | *Etiology: unknown. | ||
Clinical:<ref name=Ref_PCPBoD8_609>{{Ref PCPBoD8|609}}</ref> | |||
*Classic location: posterior shins. | |||
*Ulcerates and scars. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD8_1199>{{Ref PBoD8|1199}}</ref> | Features:<ref name=Ref_PBoD8_1199>{{Ref PBoD8|1199}}</ref> | ||
*Necrotizing granulomatous inflammation. | *Predominantly lobular process with:<ref name=medscape_en>URL: [http://www.medscape.com/viewarticle/440356_8 http://www.medscape.com/viewarticle/440356_8]. Accessed on: 11 September 2011.</ref> | ||
*Necrotizing vasculitis of small/medium sized vessels (early). | **Necrotizing granulomatous inflammation. | ||
**Necrotizing [[vasculitis]] of small/medium sized vessels (early). | |||
DDx: | DDx: | ||
*Infection. | *Infection. | ||
Images: | |||
*[http://img.medscape.com/fullsize/migrated/440/356/doj440356.fig17a.jpg Erythema induratum - low mag. (medscape.com)]. | |||
*[http://img.medscape.com/fullsize/migrated/440/356/doj440356.fig17d.jpg Erythema induratum - high mag. (medscape.com)]. | |||
=See also= | =See also= | ||
Revision as of 04:47, 11 September 2011
Panniculitis is inflammation of the adipose tissue. It is encountered in dermatopathology specimens.
General DDx
- Erythema nodosum.
- Erythema induratum.
- Self-inflicted trauma.
- Systemic lupus erythematosus.
- Weird stuff.
Specific conditions
Erythema nodosum
Causes - mnemonic NODOSUM:[1]
- NO cause (idiopathic) ~ 55% of cases.
- Drugs (sulfonamides, amoxicillin, oral contraceptives) ~ 5% of cases.
- Other infections - group A streptococci (streptococcal pharyngitis), Yersinia, chlamydia, mycobacteria, others ~ 30% of cases.
- Sarcoidosis ~ 7% of cases.
- Ulcerative colitis & Crohn's disease ~ 2% of cases.
- Malignancy (leukemia, Hodgkin's lymphoma) ~ 1% of cases
Microscopic
- Expanded septa between fat lobules - key (low power) feature.
- Neutrophils.
- Lymphocytes.
- Histiocytes.
- Fibrin.
Notes:
- No vasculitis.
- +/-Granulomas.[5]
Images:
Erythema induratum
General
Features:[3]
- Uncommon.
- Etiology: unknown.
Clinical:[4]
- Classic location: posterior shins.
- Ulcerates and scars.
Microscopic
Features:[3]
- Predominantly lobular process with:[2]
- Necrotizing granulomatous inflammation.
- Necrotizing vasculitis of small/medium sized vessels (early).
DDx:
- Infection.
Images:
See also
References
- ↑ 1.0 1.1 Schwartz, RA.; Nervi, SJ. (Mar 2007). "Erythema nodosum: a sign of systemic disease.". Am Fam Physician 75 (5): 695-700. PMID 17375516.
- ↑ 2.0 2.1 URL: http://www.medscape.com/viewarticle/440356_8. Accessed on: 11 September 2011.
- ↑ 3.0 3.1 3.2 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1199. ISBN 978-1416031215.
- ↑ 4.0 4.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 609. ISBN 978-1416054542.
- ↑ 5.0 5.1 URL: http://missinglink.ucsf.edu/lm/DermatologyGlossary/erythema_nodosum.html. Accessed on: 11 September 2011.