Difference between revisions of "Progressive transformation of germinal centers"
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==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
==Additional reading== | |||
*{{cite journal |author=Hansmann ML, Fellbaum C, Hui PK, Moubayed P |title=Progressive transformation of germinal centers with and without association to Hodgkin's disease |journal=Am. J. Clin. Pathol. |volume=93 |issue=2 |pages=219–26 |year=1990 |month=February |pmid=2405631 |doi= |url=}} | |||
*{{cite journal |author=Kojima M, Nakamura S, Motoori T, ''et al.'' |title=Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients |journal=Int. J. Surg. Pathol. |volume=11 |issue=2 |pages=101–7 |year=2003 |month=April |pmid=12754626 |doi= |url=}} | |||
[[Category:Lymph node pathology]] | [[Category:Lymph node pathology]] | ||
Revision as of 10:38, 20 July 2011
Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.
General
- Benign.
- Classically in younger patients.
- Associated with nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.[1]
Clinical:
- Asymptomatic lymphadenopathy.
Microscopic
Features:
- Follicular hyperplasia (many follicles).
- Focally large germinal centers with:
- Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
- Expanded mantle zone.
Images:
See also
References
Additional reading
- Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
- Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.