Difference between revisions of "Lung carcinoma with ALK rearrangement"
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**Typically seen in nonsmokers and younger age patients. | **Typically seen in nonsmokers and younger age patients. | ||
**Can be treated with ''[[crizotinib]]''.<ref name=pmid21475126>{{Cite journal | last1 = Crystal | first1 = AS. | last2 = Shaw | first2 = AT. | title = New targets in advanced NSCLC: EML4-ALK. | journal = Clin Adv Hematol Oncol | volume = 9 | issue = 3 | pages = 207-14 | month = Mar | year = 2011 | doi = | PMID = 21475126 }}</ref> | **Can be treated with ''[[crizotinib]]''.<ref name=pmid21475126>{{Cite journal | last1 = Crystal | first1 = AS. | last2 = Shaw | first2 = AT. | title = New targets in advanced NSCLC: EML4-ALK. | journal = Clin Adv Hematol Oncol | volume = 9 | issue = 3 | pages = 207-14 | month = Mar | year = 2011 | doi = | PMID = 21475126 }}</ref> | ||
***Resistance to ALK inhibitors may occur due mutations in kinase domain. | |||
***Ceritinib is indicated for tumor with acquired resistance to crizotinib.<ref name="pmid24670165">{{Cita publicación | apellido = Shaw | nombre = AT. | coautores = DW. Kim, R. Mehra, DS. Tan, E. Felip, LQ. Chow, DR. Camidge, J. Vansteenkiste, S. Sharma, T. De Pas, GJ. Riely | título = Ceritinib in ALK-rearranged non-small-cell lung cancer. | publicación = N Engl J Med | volume = 370 | número = 13 | páginas = 1189-97 | mes = Mar | año = 2014 | doi = 10.1056/NEJMoa1311107 | pmid = 24670165 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 03:06, 21 September 2017
Lung carcinoma with ALK rearrangement is subset of lung adenocarcinoma.
General
ALK (Anaplastic lymphoma receptor tyrosine kinase)
- Approximately 1-5% non-small cell lung carcinoma.[1]
- Typically seen in nonsmokers and younger age patients.
- Can be treated with crizotinib.[2]
- Resistance to ALK inhibitors may occur due mutations in kinase domain.
- Ceritinib is indicated for tumor with acquired resistance to crizotinib.[3]
Microscopic
Features:[1]
- Adenocarcinoma - at least focally.
- Solid signet-ring cell pattern - common.
- Mucinous cribriform pattern - common.
DDx:
Images
- Lung carcinoma with ALK rearrangement (nih.gov).[4]
- Lung carcinoma with ALK rearrangment (nih.gov)[5] - high resolution (plosone.org).
IHC
Features:[1]
- p63 +ve.
- TTF-1 +ve.
- ALK +ve.[citation needed]
Molecular
- EML4-ALK fusion -- inv(2)(p21p23).[6]
Notes:
- May be demonstrated with FISH or PCR looking for the a fusion transcript.[7]
- ALK rearrangement does not occur with EGRF mutation or KRAS mutation.[7]
See also
References
- ↑ 1.0 1.1 1.2 Yoshida, A.; Tsuta, K.; Nakamura, H.; Kohno, T.; Takahashi, F.; Asamura, H.; Sekine, I.; Fukayama, M. et al. (Aug 2011). "Comprehensive histologic analysis of ALK-rearranged lung carcinomas.". Am J Surg Pathol 35 (8): 1226-34. doi:10.1097/PAS.0b013e3182233e06. PMID 21753699.
- ↑ Crystal, AS.; Shaw, AT. (Mar 2011). "New targets in advanced NSCLC: EML4-ALK.". Clin Adv Hematol Oncol 9 (3): 207-14. PMID 21475126.
- ↑ Template:Cita publicación
- ↑ Lopes, LF.; Bacchi, CE. (Jul 2012). "Anaplastic lymphoma kinase gene rearrangement in non-small-cell lung cancer in a Brazilian population.". Clinics (Sao Paulo) 67 (7): 845-7. PMID 22892933.
- ↑ Takamochi, K.; Takeuchi, K.; Hayashi, T.; Oh, S.; Suzuki, K. (2013). "A rational diagnostic algorithm for the identification of ALK rearrangement in lung cancer: a comprehensive study of surgically treated Japanese patients.". PLoS One 8 (8): e69794. doi:10.1371/journal.pone.0069794. PMID 23936355.
- ↑ Li, Y.; Ye, X.; Liu, J.; Zha, J.; Pei, L. (Jan 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors.". Neoplasia 13 (1): 1-11. PMID 21245935.
- ↑ 7.0 7.1 Gainor, JF.; Varghese, AM.; Ou, SH.; Kabraji, S.; Awad, MM.; Katayama, R.; Pawlak, A.; Mino-Kenudson, M. et al. (Aug 2013). "ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer.". Clin Cancer Res 19 (15): 4273-81. doi:10.1158/1078-0432.CCR-13-0318. PMID 23729361.