Difference between revisions of "Smoking-related interstitial fibrosis"
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'''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory | '''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory scarring associated with [[smoking]]. | ||
==General== | ==General== | ||
Revision as of 14:45, 23 March 2017
Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.
General
- Associated with emphysema and respiratory bronchiolitis.[1]
Gross
- Subpleural and centrilobular predominance.[1]
Microscopic
Features:[1]
- Septal thickening of alveoli with:
- Thick collagen bundles - may be described as "ropy".[2]
- Hyperplastic smooth muscle fibres.
- Minimal inflammation.
DDx:
- Usual interstitial pneumonia - has inflammation.
See also
References
- ↑ 1.0 1.1 1.2 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
- ↑ Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.