Difference between revisions of "E-cadherin"
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'''E-cadherin''' is a common [[immunostain]]. | '''E-cadherin''' is a common [[immunostain]]. | ||
Mutations in the epithelial cadherin gene (''E-cadherin''), also known as ''CDH1'', are associated with [[hereditary diffuse gastric cancer syndrome | Mutations in the epithelial cadherin gene (''E-cadherin''), also known as ''CDH1'', are associated with [[hereditary diffuse gastric cancer syndrome]].<ref name=omim137215>{{OMIM|137215}}</ref><Ref>{{OMIM|192090}}</ref> | ||
==Negative== | ==Negative== | ||
Revision as of 05:30, 23 January 2017
E-cadherin is a common immunostain.
Mutations in the epithelial cadherin gene (E-cadherin), also known as CDH1, are associated with hereditary diffuse gastric cancer syndrome.[1][2]
Negative
- Lobular breast carcinoma.
- Atypical lobular hyperplasia.
- Lobular carcinoma in situ.
- Gastric adenocarcinoma, diffuse type.
Images
ALH with E-cadherin loss of staining - intermed. mag.
ALH with E-cadherin loss of staining - high mag.
Normal
Normal stain pattern:
- Complete membrane staining.
Comment:
- Partial loss is considered negative staining.
Images
Benign breast - intermed. mag.
Benign breast - high mag.
Benign breast - high mag.
