Difference between revisions of "Eosinophilic granulomatosis with polyangiitis"
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*'''F'''ever. | *'''F'''ever. | ||
*'''E'''osinophilia. | *'''E'''osinophilia. | ||
Other clinical features - may be present:<ref name=pmid27671089 >{{Cite journal | last1 = Cottin | first1 = V. | last2 = Bel | first2 = E. | last3 = Bottero | first3 = P. | last4 = Dalhoff | first4 = K. | last5 = Humbert | first5 = M. | last6 = Lazor | first6 = R. | last7 = Sinico | first7 = RA. | last8 = Sivasothy | first8 = P. | last9 = Wechsler | first9 = ME. | title = Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss). | journal = Autoimmun Rev | volume = | issue = | pages = | month = Sep | year = 2016 | doi = 10.1016/j.autrev.2016.09.018 | PMID = 27671089 }}</ref> | |||
*ANCA. | |||
*Weight loss. | |||
*Myalgias. | |||
*Arthralgias | |||
*Glomerulonephritis. | |||
*Hematuria. | |||
Notes: | Notes: | ||
Revision as of 21:26, 28 November 2016
| Eosinophilic granulomatosis with polyangiitis | |
|---|---|
| Diagnosis in short | |
 Eosinophilic granulomatosis with polyangiitis. H&E stain. | |
|
| |
| LM | small vessel vasculitis with abundant eosinophils and granulomas |
| LM DDx | eosinophilic vasculitis associated with a connective tissue disease |
| Site | blood vessels |
|
| |
| Associated Dx | asthma |
| Signs | fever |
| Prevalence | rare |
Eosinophilic granulomatosis with polyangiitis, previously known as Churg-Strauss syndrome,[1] is a type of vasculitis.
General
Defining features - memory device GAFE:
- Granulomata.
- Asthma.
- Fever.
- Eosinophilia.
Other clinical features - may be present:[2]
- ANCA.
- Weight loss.
- Myalgias.
- Arthralgias
- Glomerulonephritis.
- Hematuria.
Notes:
- Similar to Granulomatosis with polyangiitis (Wegener's granulomatosis) - classically c-ANCA +ve, and microscopic polyangiitis.[3]
Microscopic
Features:
- Small vessel vasculitis.
- Abundant eosinophils.
- Granulomas.
DDx:
- Eosinophilic vasculitis associated with a connective tissue disease.[4]
Images
CSS - high mag. (WC)
CSS - very high mag. (WC)
See also
References
- ↑ Stone, JR.; Bruneval, P.; Angelini, A.; Bartoloni, G.; Basso, C.; Batoroeva, L.; Buja, LM.; Butany, J. et al. "Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases.". Cardiovasc Pathol 24 (5): 267-78. doi:10.1016/j.carpath.2015.05.001. PMID 26051917.
- ↑ Cottin, V.; Bel, E.; Bottero, P.; Dalhoff, K.; Humbert, M.; Lazor, R.; Sinico, RA.; Sivasothy, P. et al. (Sep 2016). "Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss).". Autoimmun Rev. doi:10.1016/j.autrev.2016.09.018. PMID 27671089.
- ↑ URL: http://emedicine.medscape.com/article/334024-overview. Accessed on: 22 January 2011.
- ↑ Chen, KR.; Su, WP.; Pittelkow, MR.; Conn, DL.; George, T.; Leiferman, KM. (Aug 1996). "Eosinophilic vasculitis in connective tissue disease.". J Am Acad Dermatol 35 (2 Pt 1): 173-82. PMID 8708015.