Difference between revisions of "S-100"
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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
| Image = Mammary_analogue_secretory_carcinoma_(S100immunohistochemstry,_low_power).jpg | |||
| Width = | |||
| Caption = S-100 staining in a [[MASC]]. | |||
| Abbrev = | |||
| Synonyms = | |||
| Similar = | |||
| Clones = | |||
| Use = [[malignant melanoma]], assess [[perineural invasion]], undifferentiated malignancy | |||
| Subspecial = | |||
| Pattern = nucleus and cytoplasm | |||
| Positive = benign: nerves, adipose tissue; tumour/other: [[granular cell tumour]], [[Rosai-Dorfman disease]]; malignant: [[malignant melanoma]], [[clear cell sarcoma]], [[malignant peripheral nerve shealth tumour]] | |||
| Negative = | |||
| Other = | |||
}} | |||
'''S-100''', also '''S100''', is a commonly used [[immunostain]]. It marks nerves. | '''S-100''', also '''S100''', is a commonly used [[immunostain]]. It marks nerves. | ||
Revision as of 22:34, 31 July 2016
| S-100 | |
|---|---|
| Immunostain in short | |
.jpg) S-100 staining in a MASC. | |
| Use | malignant melanoma, assess perineural invasion, undifferentiated malignancy |
| Normal staining pattern | nucleus and cytoplasm |
| Positive | benign: nerves, adipose tissue; tumour/other: granular cell tumour, Rosai-Dorfman disease; malignant: malignant melanoma, clear cell sarcoma, malignant peripheral nerve shealth tumour |
S-100, also S100, is a commonly used immunostain. It marks nerves.
Positive
- Nerves.
- Schwannoma.
- Mature adipose tissue.
- Interdigitating dendritic cells.[1]
- Langerhans cell histiocytosis.
- Rosai-Dorfman disease.
- Chordoma - also keratin positive (AE1/AE3, CK19, CAM5.2).[2]
- Granular cell tumour.
Malignant tumours
- Malignant melanoma - almost 100% sensitive.
- Malignant peripheral nerve sheath tumour.
- Clear cell sarcoma.
- Mammary analogue secretory carcinoma.
See also
References
- ↑ Mesquita, RA.; de Araújo, VC.; Paes, RA.; Nunes, FD.; de Souza, SC.. "Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.". J Appl Oral Sci 17 (3): 248-53. PMID 19466261.
- ↑ Shen, J.; Shi, Q.; Lu, J.; Wang, DL.; Zou, TM.; Yang, HL.; Zhu, GQ. (Dec 2013). "Histological study of chordoma origin from fetal notochordal cell rests.". Spine (Phila Pa 1976) 38 (25): 2165-70. doi:10.1097/BRS.0000000000000010. PMID 24296480.