Difference between revisions of "Programmed cell death 1"
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Uncertain whether it binds PD-L1: | Uncertain whether it binds PD-L1: | ||
*Pidilizumab. | *Pidilizumab. | ||
==IHC== | |||
*There is no standard PD-1 antibody; each drug company has its own clone. | |||
==See also== | ==See also== | ||
Revision as of 19:21, 10 July 2016
Programmed cell death 1, abbreviated PDCD1 and PD1,[1] is a protein (and gene) with an important role in immune system regulation and cancer. It is found on T lymphocytes.
It is also known as CD279.
PD1 binds with programmed death-ligand 1 (dealt with separately) and programmed death-ligand 2.[2]
Background
Cytotoxic T cell function is regulated by receptor pairs found on the tumour and lymphocyte:[2]
| Function | Tumour cell | T cell |
|---|---|---|
| Antigen presentation | MHC | TCR |
| Signal inhibition | PD-1 | PD-L1 (CD274), PD-L2 (CD273) |
Drugs
- Pembrolizumab.
- Nivolumab.
- Atezolizumab.
- Durvalumab.
- Avelumab.
Uncertain whether it binds PD-L1:
- Pidilizumab.
IHC
- There is no standard PD-1 antibody; each drug company has its own clone.
See also
- Programmed death-ligand 1 (PD-L1).
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 600244
- ↑ 2.0 2.1 Ribas, A. (Jun 2012). "Tumor immunotherapy directed at PD-1.". N Engl J Med 366 (26): 2517-9. doi:10.1056/NEJMe1205943. PMID 22658126.