Difference between revisions of "Follicular dendritic cell sarcoma"
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{{ Infobox diagnosis | |||
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| Micro = oval or spindle-shaped cellular & nuclear morphology, variable architecture (sheets, fascicles, whorles, storiform pattern), nuclei with small nucleoli and clear or dispersed chromatin, multinucleated cells, interspersed small lymphocytes, +/-necrosis, +/-marked nuclear atypia, +/-abundant mitoses. | |||
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| LMDDx = [[histiocytic sarcoma]], [[thymoma]], other [[spindle cell lesions]] | |||
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| IHC = CD21 +ve, CD35 +ve, Ki-M4p +ve, Ki-FDRC1p +ve, vimentin +ve | |||
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| Prevalence = very rare | |||
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| Tx = excision | |||
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'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour. | '''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour. | ||
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DDx: | DDx: | ||
*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref> | *[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref> | ||
*[[Thymoma]]. | |||
*[[Spindle cell lesions]]. | *[[Spindle cell lesions]]. | ||
Revision as of 01:07, 2 June 2016
| Follicular dendritic cell sarcoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | oval or spindle-shaped cellular & nuclear morphology, variable architecture (sheets, fascicles, whorles, storiform pattern), nuclei with small nucleoli and clear or dispersed chromatin, multinucleated cells, interspersed small lymphocytes, +/-necrosis, +/-marked nuclear atypia, +/-abundant mitoses. |
| LM DDx | histiocytic sarcoma, thymoma, other spindle cell lesions |
| IHC | CD21 +ve, CD35 +ve, Ki-M4p +ve, Ki-FDRC1p +ve, vimentin +ve |
| Prevalence | very rare |
| Treatment | excision |
Follicular dendritic cell sarcoma, abbreviated FDCS, is a very rare malignant tumour.
It is also known as follicular dendritic cell tumour (abbreviated FDCT).[1]
Other possible names are: dendritic reticulum cell sarcoma, (???) follicular dendritic cell neoplasm. (???)
General
- Very rare.
- Behave like a low-grade sarcoma.[2]
- Reported association with Castleman disease (hyaline-vascular type).[2]
Microscopic
Features:[2]
- Oval or spindle-shaped cellular & nuclear morphology.
- Variable architecture (sheets, fascicles, whorles, storiform pattern).
- Nuclei:
- Small nucleoli.
- Clear or dispersed chromatin.
- Multinucleated cells.
- Interspersed small lymphocytes - distinctive feature.
- +/-Necrosis.
- +/-Marked nuclear atypia.
- +/-Abundant mitoses.
DDx:
Images
- FDCS (ajronline.org).[1]
- DRCS (webpathology.com).
- FDCS (npplweb.com).[4]
- FDCT - several crappy images (upmc.edu).
- FDCS - several images (upmc.edu).
IHC
Features:[2]
- CD21 +ve.
- CD35 +ve.
- Ki-M4p +ve
- Ki-FDRC1p +ve.
- Vimentin +ve.
- S-100 +ve/-ve.
- Muscle-specific actin +ve/-ve.
- EMA +ve/-ve.
See also
References
- ↑ 1.0 1.1 Leipsic, JA.; McAdams, HP.; Sporn, TA. (Jun 2007). "Follicular dendritic cell sarcoma of the mediastinum.". AJR Am J Roentgenol 188 (6): W554-6. doi:10.2214/AJR.04.1530. PMID 17515347.
- ↑ 2.0 2.1 2.2 2.3 Perez-Ordoñez, B.; Rosai, J. (May 1998). "Follicular dendritic cell tumor: review of the entity.". Semin Diagn Pathol 15 (2): 144-54. PMID 9606805.
- ↑ Alexiev, BA.; Sailey, CJ.; McClure, SA.; Ord, RA.; Zhao, XF.; Papadimitriou, JC. (2007). "Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component.". Diagn Pathol 2: 7. doi:10.1186/1746-1596-2-7. PMID 17324277. http://www.diagnosticpathology.org/content/2/1/7.
- ↑ URL: http://www.npplweb.com/wjsmro/fulltext/2/1. Accessed on: September 13, 2014.