Difference between revisions of "Langerhans cell histiocytosis"
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Langerhans cells histiocytes | *Langerhans cells histiocytes - '''key feature'''. | ||
**Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm. | **Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm. | ||
***Nucleus may look like a "coffee bean", i.e. have nuclear grooves (similar to those in [[papillary thyroid carcinoma]]) -- appearance dependent on the rotation of the nucleus.<ref>BN. 15 March 2011.</ref> | ***Nucleus may look like a "coffee bean", i.e. have nuclear grooves (similar to those in [[papillary thyroid carcinoma]]) -- appearance dependent on the rotation of the nucleus.<ref>BN. 15 March 2011.</ref> | ||
Revision as of 03:45, 16 March 2011
Langerhans cell histiocytosis, abbreviated LCH, is a rare genetic disorder of tissue macrophages.
General
- Looks like eosinophilic granuloma of the lung - see medical lung diseases.
Microscopic
Features:
- Langerhans cells histiocytes - key feature.
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- Nucleus may look like a "coffee bean", i.e. have nuclear grooves (similar to those in papillary thyroid carcinoma) -- appearance dependent on the rotation of the nucleus.[1]
- Chromatin pattern: fine granular, light gray.
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- +/-Eosinophils - often prominent.
Images:
IHC
- CD1a +ve.
- S100 +ve.
See also
References
- ↑ BN. 15 March 2011.