Difference between revisions of "Small cell carcinoma of the prostate gland"
Jump to navigation
Jump to search
(split out) |
|||
| Line 5: | Line 5: | ||
*Most common small cell carcinoma outside of the lung.<ref name=pmid22110988/> | *Most common small cell carcinoma outside of the lung.<ref name=pmid22110988/> | ||
*Poor prognosis. | *Poor prognosis. | ||
*Not graded (ISUP 2005 consensus on [[Gleason score]]<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref>). | *Not [[prostate cancer grading|graded]] ([[ISUP]] 2005 consensus on [[Gleason score]]<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref>). | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 04:12, 24 January 2016
Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.
General
- Very rare.[1]
- Most common small cell carcinoma outside of the lung.[1]
- Poor prognosis.
- Not graded (ISUP 2005 consensus on Gleason score[2]).
Microscopic
Features:
- Small cells with:
- Nuclear moulding.
- Stippled chromatin.
- High NC ratio.
- +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[1]
Notes:
- Similar to small cell carcinoma of the lung.
- High-grade squamoid component favours metastatic urothelial carcinoma.
- UCC usu. HWCK +ve.
DDx:
- Small cell carcinoma of the urinary bladder.
- Lymphoma, large cell.
- Other small round cell tumours.
Images
www
- SmCC of the prostate - low mag. (webpathology.com).
- SmCC of the prostate - high mag. (webpathology.com).
- SmCC of the prostate - low mag. (nih.gov).
- SmCC of the prostate - high mag. (nih.gov).
IHC
Features:[1]
- PSA weak +ve/-ve.
- Chromogranin +ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
- ↑ Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.