Difference between revisions of "Perineurioma"
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'''Perineurioma''' is an uncommon benign [[peripheral nerve sheath tumour]]. | |||
==General== | |||
*Benign tumour derived from perineurial cells (intraneural or soft tissue). | |||
**ICD-O 9571/0 | |||
** WHO grade I | |||
*Rarely malignant soft tissue perineurioma. | |||
Variant: | |||
*Reticular perineurioma.<ref name=pmid11257623>{{Cite journal | last1 = Graadt van Roggen | first1 = JF. | last2 = McMenamin | first2 = ME. | last3 = Belchis | first3 = DA. | last4 = Nielsen | first4 = GP. | last5 = Rosenberg | first5 = AE. | last6 = Fletcher | first6 = CD. | title = Reticular perineurioma: a distinctive variant of soft tissue perineurioma. | journal = Am J Surg Pathol | volume = 25 | issue = 4 | pages = 485-93 | month = Apr | year = 2001 | doi = | PMID = 11257623 }}</ref> | |||
==Macroscopy== | |||
*Intraneural perineurioma: segmental tubular enlargement of the nerve. | |||
*Soft tissue perineurioma: Well circumscribed, but not encapsulated. | |||
==Microscopic== | |||
Features:<ref name=Ref_Sternberg5_424>{{Ref Sternberg5|424}}</ref> | |||
*Perineural epithelioid cells. | |||
**Abundant pale, fluffy appearing cytoplasm. | |||
Note: | |||
*May be intraneural.<ref name=Ref_Sternberg5_424>{{Ref Sternberg5|424}}</ref> | |||
**Typical pseudo-onion bulbs. | |||
**Long considered hypertrophic neuropathy. | |||
**Rare (less than 1% of all nerve sheath tumours). | |||
DDx: | |||
*[[Neuroma]]. | |||
*[[Neurofibroma]]. | |||
*[[Schwannoma]]. | |||
**S100 +ve, EMA -ve.<ref name=Ref_Sternberg5_424>{{Ref Sternberg5|424}}</ref> | |||
*[[Liposarcoma]] - reticular perineurioma. | |||
Images: | |||
*[http://www.conganat.org/seap/reuniones/almagro2000/scruz/tnerviog5.htm Perineurioma (conganat.org)]. | |||
<gallery> | |||
File:Perineurioma,_HE_stain.jpg | Pseudo-onion bulbs in a intraneural perioneurioma (WC/jensflorian) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid15958848>{{Cite journal | last1 = Hornick | first1 = JL. | last2 = Fletcher | first2 = CD. | title = Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. | journal = Am J Surg Pathol | volume = 29 | issue = 7 | pages = 845-58 | month = Jul | year = 2005 | doi = | PMID = 15958848 }}</ref><ref name=pmid1497116>{{Cite journal | last1 = Tsang | first1 = WY. | last2 = Chan | first2 = JK. | last3 = Chow | first3 = LT. | last4 = Tse | first4 = CC. | title = Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. | journal = Am J Surg Pathol | volume = 16 | issue = 8 | pages = 756-63 | month = Aug | year = 1992 | doi = | PMID = 1497116 }}</ref> | |||
*S100 -ve. | |||
*EMA +ve. | |||
*CD34 ~65% +ve.<ref name=pmid15958848/> | |||
==See also== | |||
*[[Peripheral nerve sheath tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||
[[Category:Peripheral nerve sheath tumours]] | [[Category:Peripheral nerve sheath tumours]] | ||
Revision as of 14:17, 29 August 2018
Perineurioma is an uncommon benign peripheral nerve sheath tumour.
General
- Benign tumour derived from perineurial cells (intraneural or soft tissue).
- ICD-O 9571/0
- WHO grade I
- Rarely malignant soft tissue perineurioma.
Variant:
- Reticular perineurioma.[1]
Macroscopy
- Intraneural perineurioma: segmental tubular enlargement of the nerve.
- Soft tissue perineurioma: Well circumscribed, but not encapsulated.
Microscopic
Features:[2]
- Perineural epithelioid cells.
- Abundant pale, fluffy appearing cytoplasm.
Note:
- May be intraneural.[2]
- Typical pseudo-onion bulbs.
- Long considered hypertrophic neuropathy.
- Rare (less than 1% of all nerve sheath tumours).
DDx:
- Neuroma.
- Neurofibroma.
- Schwannoma.
- S100 +ve, EMA -ve.[2]
- Liposarcoma - reticular perineurioma.
Images:
Pseudo-onion bulbs in a intraneural perioneurioma (WC/jensflorian)
IHC
- S100 -ve.
- EMA +ve.
- CD34 ~65% +ve.[3]
See also
References
- ↑ Graadt van Roggen, JF.; McMenamin, ME.; Belchis, DA.; Nielsen, GP.; Rosenberg, AE.; Fletcher, CD. (Apr 2001). "Reticular perineurioma: a distinctive variant of soft tissue perineurioma.". Am J Surg Pathol 25 (4): 485-93. PMID 11257623.
- ↑ 2.0 2.1 2.2 Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 424. ISBN 978-0781779425.
- ↑ 3.0 3.1 Hornick, JL.; Fletcher, CD. (Jul 2005). "Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features.". Am J Surg Pathol 29 (7): 845-58. PMID 15958848.
- ↑ Tsang, WY.; Chan, JK.; Chow, LT.; Tse, CC. (Aug 1992). "Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma.". Am J Surg Pathol 16 (8): 756-63. PMID 1497116.