Difference between revisions of "Intramucosal colorectal carcinoma"
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*[[Colorectal adenocarcinoma]] is defined by invasion into the submucosa. | *[[Colorectal adenocarcinoma]] is defined by invasion into the submucosa. | ||
**This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria. | **This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria. | ||
**Rationale: nasty (cancer-like) cells in lamina propria only do not have metastatic potential as there are no lymphatics in the colorectal lamina propria.<ref>{{Cite journal | last1 = Lewin | first1 = MR. | last2 = Fenton | first2 = H. | last3 = Burkart | first3 = AL. | last4 = Sheridan | first4 = T. | last5 = Abu-Alfa | first5 = AK. | last6 = Montgomery | first6 = EA. | title = Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1882-6 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318057fac2 | PMID = 18043043 }}</ref> | **Rationale: nasty (cancer-like) cells in lamina propria only do not have [[metastasis|metastatic]] potential as there are no lymphatics in the colorectal lamina propria.<ref>{{Cite journal | last1 = Lewin | first1 = MR. | last2 = Fenton | first2 = H. | last3 = Burkart | first3 = AL. | last4 = Sheridan | first4 = T. | last5 = Abu-Alfa | first5 = AK. | last6 = Montgomery | first6 = EA. | title = Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1882-6 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318057fac2 | PMID = 18043043 }}</ref> | ||
==See also== | ==See also== | ||
Revision as of 01:49, 23 October 2015
Intramucosal colorectal carcinoma is a confusing term for high grade (colorectal) dysplasia that should be avoided.[1]
Background
- Colorectal adenocarcinoma is defined by invasion into the submucosa.
- This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria.
- Rationale: nasty (cancer-like) cells in lamina propria only do not have metastatic potential as there are no lymphatics in the colorectal lamina propria.[2]
See also
References
- ↑ Fleming, M.; Ravula, S.; Tatishchev, SF.; Wang, HL. (Sep 2012). "Colorectal carcinoma: Pathologic aspects.". J Gastrointest Oncol 3 (3): 153-73. doi:10.3978/j.issn.2078-6891.2012.030. PMID 22943008.
- ↑ Lewin, MR.; Fenton, H.; Burkart, AL.; Sheridan, T.; Abu-Alfa, AK.; Montgomery, EA. (Dec 2007). "Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases.". Am J Surg Pathol 31 (12): 1882-6. doi:10.1097/PAS.0b013e318057fac2. PMID 18043043.