Difference between revisions of "Colorectal xanthomatous polyp"

Colorectal xanthomatous polyp
	Diagnosis in short
	; Colorectal xanthomatous polyp. H&E stain.
LM	abundant foamy histiocytes in the superficial lamina propria +/- superficial serrations (hyperplastic features)
LM DDx	hyperplastic polyp, signet ring cell carcinoma, others
IHC	CD68 +ve, pankeratin -ve
Site	colon, rectum
Associated Dx	+/-hyperlipidemia
Prevalence	uncommon
Endoscopy	polyp - red or yellow colour
Prognosis	benign
Clin. DDx	other colorectal polyps

Latest revision as of 19:13, 24 October 2022

The colorectal xanthomatous polyp, also colorectal xanthoma, is a rare benign intestinal polyp.

Rectal xanthoma, colonic xanthoma, rectal xanthelasma and colonic xanthelasma redirect here.

Colorectal xanthomatous polyp may be abbreviated CXP.

General

Rare.^[1]
May be associated with hyperlipidemia (7/25 patients in one series^[2]).

Gross

Usually red colour.^[2]
- Classically described as yellow.^[1]^[2]

Microscopic

Features:

Abundant foamy histiocytes in the superficial lamina propria.
+/-Superficial serrations (hyperplastic features).
- Seen in ~80% of cases.^[2]

DDx:

Images

XP - very low mag.
XP - low mag.
XP - intermed. mag.
XP - intermed. mag.
XP - high mag.
XP - very high mag.
XP - very high mag.

Stains

ZN stain -ve.
PAS stain -ve.

IHC

CD68 +ve (foamy histiocytes).^[1]
Pankeratin -ve.

Sign out

Polyp, Rectum, Polypectomy or Biopsy:
- Xanthomatous polyp with hyperplastic features, see comment.
- NEGATIVE for dysplasia.

COMMENT:
Xanthomatous polyps may be seen in the context of hyperlipidemia.[1]  A lipid 
profile could be considered.

1. APMIS 112 (1): 3-10. PMID: 14961968.

Block letters

POLYP, SIGMOID COLON, POLYPECTOMY:
- XANTHOMATOUS POLYP WITH HYPERPLASTIC FEATURES.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
Xanthomatous polyps may be seen in the context of hyperlipidemia.[1]  A lipid 
profile could be considered.

1. APMIS 112 (1): 3-10. PMID: 14961968.

References

↑ ^1.0 ^1.1 ^1.2 Miliauskas, JR. (Apr 2002). "Rectosigmoid (colonic) xanthoma: a report of four cases and review of the literature.". Pathology 34 (2): 144-7. PMID 12009096.
↑ ^2.0 ^2.1 ^2.2 ^2.3 Nakasono, M.; Hirokawa, M.; Muguruma, N.; Okahisa, T.; Okamura, S.; Ito, S.; Miyamoto, H.; Wada, S. et al. (Jan 2004). "Colorectal xanthomas with polypoid lesion: report of 25 cases.". APMIS 112 (1): 3-10. PMID 14961968.

[pmid12009096-1] 1.0 ^1.1 ^1.2 Miliauskas, JR. (Apr 2002). "Rectosigmoid (colonic) xanthoma: a report of four cases and review of the literature.". Pathology 34 (2): 144-7. PMID 12009096.

[pmid14961968-2] 2.0 ^2.1 ^2.2 ^2.3 Nakasono, M.; Hirokawa, M.; Muguruma, N.; Okahisa, T.; Okamura, S.; Ito, S.; Miyamoto, H.; Wada, S. et al. (Jan 2004). "Colorectal xanthomas with polypoid lesion: report of 25 cases.". APMIS 112 (1): 3-10. PMID 14961968.

[1]

[2]