Difference between revisions of "Penile intraepithelial neoplasia"
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===Subclassification=== | ===Subclassification=== | ||
Subclassified based on the role of [[HPV]],<ref>{{Cite journal | last1 = Velazquez | first1 = EF. | last2 = Chaux | first2 = A. | last3 = Cubilla | first3 = AL. | title = Histologic classification of penile intraepithelial neoplasia. | journal = Semin Diagn Pathol | volume = 29 | issue = 2 | pages = 96-102 | month = May | year = 2012 | doi = | PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]: | Subclassified based on the role of [[HPV]],<ref>{{Cite journal | last1 = Velazquez | first1 = EF. | last2 = Chaux | first2 = A. | last3 = Cubilla | first3 = AL. | title = Histologic classification of penile intraepithelial neoplasia. | journal = Semin Diagn Pathol | volume = 29 | issue = 2 | pages = 96-102 | month = May | year = 2012 | doi = | PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]: | ||
*Conventional PeIN. | *Conventional PeIN (cPeIN). | ||
*Differentiated PeIN. | *Differentiated PeIN (dPeIN). | ||
==IHC== | ==IHC== | ||
Revision as of 04:04, 22 July 2015
Penile intraepithelial neoplasia, abbreviated PeIN, is the precursor of squamous cell carcinoma of the penis.
It may be abbreviated PIN;[1] however, this can cause confusion with the prostatic intraepithelial neoplasia (the presursor of prostate carcinoma).
General
- Not very common overall.
- Typically seen adjacent to squamous cell carcinoma of the penis.
Microscopic
See vulvar intraepithelial neoplasia.
DDx:
Subclassification
Subclassified based on the role of HPV,[2] as in vulvar intraepithelial neoplasia:
- Conventional PeIN (cPeIN).
- Differentiated PeIN (dPeIN).
IHC
- p16 -ve in dPeIN,[3] +ve in cPeIN.
See also
References
- ↑ Porter, WM.; Francis, N.; Hawkins, D.; Dinneen, M.; Bunker, CB. (Dec 2002). "Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases.". Br J Dermatol 147 (6): 1159-65. PMID 12452865.
- ↑ Velazquez, EF.; Chaux, A.; Cubilla, AL. (May 2012). "Histologic classification of penile intraepithelial neoplasia.". Semin Diagn Pathol 29 (2): 96-102. PMID 22641959.
- ↑ Oertell, J.; Caballero, C.; Iglesias, M.; Chaux, A.; Amat, L.; Ayala, E.; Rodríguez, I.; Velázquez, EF. et al. (May 2011). "Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence.". Histopathology 58 (6): 925-33. doi:10.1111/j.1365-2559.2011.03816.x. PMID 21585428.