Difference between revisions of "Micropapillary urothelial carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Urothelial carcinoma with micropapillary features -- intermed mag.jpg | |||
| Width = | |||
| Caption = Urothelial carcinoma with micropapillary features. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = (subtype of [[urothelial carcinoma]]) | |||
| LMDDx = conventional [[urothelial carcinoma]], other micropapillary carcinomas ([[metastases]]) | |||
| Stains = | |||
| IHC = CK7 +ve, CK20 +ve/-ve, GATA3 +ve, p63 -ve/+ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urothelium]] - [[urinary bladder]], [[ureter]], renal pelvis, [[urethra]] (males) | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = [[hematuria]] (typical presentation) | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor (aggressive course) | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Micropapillary urothelial carcinoma''' is an aggressive variant of [[urothelial carcinoma]].<ref name=pmid21080874>{{Cite journal | last1 = Compérat | first1 = E. | last2 = Roupret | first2 = M. | last3 = Yaxley | first3 = J. | last4 = Reynolds | first4 = J. | last5 = Varinot | first5 = J. | last6 = Ouzaïd | first6 = I. | last7 = Cussenot | first7 = O. | last8 = Samaratunga | first8 = H. | title = Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi = 10.3109/00313025.2010.522173 | PMID = 21080874 }}</ref> | '''Micropapillary urothelial carcinoma''' is an aggressive variant of [[urothelial carcinoma]].<ref name=pmid21080874>{{Cite journal | last1 = Compérat | first1 = E. | last2 = Roupret | first2 = M. | last3 = Yaxley | first3 = J. | last4 = Reynolds | first4 = J. | last5 = Varinot | first5 = J. | last6 = Ouzaïd | first6 = I. | last7 = Cussenot | first7 = O. | last8 = Samaratunga | first8 = H. | title = Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi = 10.3109/00313025.2010.522173 | PMID = 21080874 }}</ref> | ||
Revision as of 09:24, 15 June 2015
| Micropapillary urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Urothelial carcinoma with micropapillary features. H&E stain. | |
| Subtypes | (subtype of urothelial carcinoma) |
| LM DDx | conventional urothelial carcinoma, other micropapillary carcinomas (metastases) |
| IHC | CK7 +ve, CK20 +ve/-ve, GATA3 +ve, p63 -ve/+ve |
| Site | urothelium - urinary bladder, ureter, renal pelvis, urethra (males) |
|
| |
| Signs | hematuria (typical presentation) |
| Prevalence | rare |
| Prognosis | poor (aggressive course) |
Micropapillary urothelial carcinoma is an aggressive variant of urothelial carcinoma.[1]
General
Microscopic
Features:[1]
- Micropapillae.
- Quantity of micropapillary (percentage) is variable.[2]
- Conventional urothelial carcinoma (typical).
DDx:
- Metastasis (breast, ovary, lung, pancreas, salivary gland).
Images
Case
UCCMPF - low mag.
UCCMPF - low mag.
UCCMPF - intermed. mag.
UCCMPF - high mag.
UCCMPF - high mag.
UCCMPF - very high mag.
www
IHC
Features:
Others:[3]
- p63 -ve/+ve.
- p40 -ve/+ve.
Sign out
- Report percentage of micropapillary pattern - suggested.[citation needed]
See also
References
- ↑ 1.0 1.1 1.2 Compérat, E.; Roupret, M.; Yaxley, J.; Reynolds, J.; Varinot, J.; Ouzaïd, I.; Cussenot, O.; Samaratunga, H. (Dec 2010). "Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases.". Pathology 42 (7): 650-4. doi:10.3109/00313025.2010.522173. PMID 21080874.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chatterjee, D.; Das, A.; Radotra, BD.. "Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study.". Indian J Pathol Microbiol 58 (1): 2-6. doi:10.4103/0377-4929.151153. PMID 25673582.
- ↑ 3.0 3.1 Lin, X.; Zhu, B.; Villa, C.; Zhong, M.; Kundu, S.; Rohan, SM.; Yang, XJ. (Sep 2014). "The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma.". Hum Pathol 45 (9): 1824-9. doi:10.1016/j.humpath.2014.04.015. PMID 24993315.