Difference between revisions of "Miscellaneous ovarian tumours"

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*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
*Proposed name: ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal  | last1 = Foulkes | first1 = WD. | last2 = Clarke | first2 = BA. | last3 = Hasselblatt | first3 = M. | last4 = Majewski | first4 = J. | last5 = Albrecht | first5 = S. | last6 = McCluggage | first6 = WG. | title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. | journal = J Pathol | volume = 233 | issue = 3 | pages = 209-14 | month = Jul | year = 2014 | doi = 10.1002/path.4362 | PMID = 24752781 }}</ref>
*Proposed name: ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal  | last1 = Foulkes | first1 = WD. | last2 = Clarke | first2 = BA. | last3 = Hasselblatt | first3 = M. | last4 = Majewski | first4 = J. | last5 = Albrecht | first5 = S. | last6 = McCluggage | first6 = WG. | title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. | journal = J Pathol | volume = 233 | issue = 3 | pages = 209-14 | month = Jul | year = 2014 | doi = 10.1002/path.4362 | PMID = 24752781 }}</ref>
 
{{Main|Ovarian small cell carcinoma of the hypercalcemic type}}
===General===
*Hypercalcemia.<ref name=pmid7943531>{{Cite journal  | last1 = Young | first1 = RH. | last2 = Oliva | first2 = E. | last3 = Scully | first3 = RE. | title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. | journal = Am J Surg Pathol | volume = 18 | issue = 11 | pages = 1102-16 | month = Nov | year = 1994 | doi =  | PMID = 7943531 }}</ref>
*Very rare.
*Most common undifferentiated ovarian malignancy in individuals less than 40 years old.<ref name=pmid24658002/>
*Associated with SMARCA4 mutations - may be familial.<ref name=pmid24658002>{{cite journal |author=Witkowski L, Carrot-Zhang J, Albrecht S, ''et al.'' |title=Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type |journal=Nat. Genet. |volume=46 |issue=5 |pages=438–43 |year=2014 |month=May |pmid=24658002 |doi=10.1038/ng.2931 |url=}}</ref>
 
===Microscopic===
Features:<ref name=pmid7943531/>
*Small cell carcinoma.
*Follicle-like spaces.
 
DDx:
*[[Small cell carcinoma of the lung]].
*[[Small cell carcinoma of the cervix]].
*[[Sertoli-Leydig cell tumour]].
*[[Juvenile granulosa cell tumour]].
 
====Images====
www:
*[http://webpathology.com/image.asp?n=6&Case=531 OSSCHT - low mag. (webpathology.com)].
*[http://webpathology.com/image.asp?case=531&n=5 OSSCHT - high mag. (webpathology.com)].
<gallery>
Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_low_mag.jpg | OSSCHT - low mag. (WC)
Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_intermed_mag.jpg | OSSCHT - intermed. mag. (WC)
Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_high_mag.jpg | OSSCHT - high mag. (WC)
Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_very_high_mag.jpg | OSSCHT - very high mag. (WC)
</gallery>
 
===IHC===
Features:<ref name=pmid17727473>{{Cite journal  | last1 = Carlson | first1 = JW. | last2 = Nucci | first2 = MR. | last3 = Brodsky | first3 = J. | last4 = Crum | first4 = CP. | last5 = Hirsch | first5 = MS. | title = Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. | journal = Histopathology | volume = 51 | issue = 3 | pages = 305-12 | month = Sep | year = 2007 | doi = 10.1111/j.1365-2559.2007.02790.x | PMID = 17727473 }}</ref>
*WT-1 +ve.
*TTF-1 -ve.
*HPV -ve.
*p16 +ve/-ve.


=See also=
=See also=

Revision as of 14:07, 6 June 2016

The article collects miscellaneous ovarian tumours, as per the WHO classification.[1]

Ovarian small cell carcinoma of the pulmonary type

See: Small cell carcinoma.

Ovarian small cell carcinoma of the hypercalcemic type

  • Abbreviated OSSCHT.
  • AKA small cell carcinoma, hypercalcemic type, AKA small cell carcinoma of the ovary, hypercalcemic type.
  • Proposed name: Malignant rhabdoid tumour of the ovary (MRTO). [2]
Main article: Ovarian small cell carcinoma of the hypercalcemic type

See also

References

  1. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 403. ISBN 978-0781765275.
  2. ↑ Foulkes, WD.; Clarke, BA.; Hasselblatt, M.; Majewski, J.; Albrecht, S.; McCluggage, WG. (Jul 2014). "No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour.". J Pathol 233 (3): 209-14. doi:10.1002/path.4362. PMID 24752781.
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