Difference between revisions of "CNS cytopathology"
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*Meningioma.<ref name=pmid7962615>{{cite journal |author=Ironside JW |title=Update on central nervous system cytopathology. II. Brain smear technique |journal=J. Clin. Pathol. |volume=47 |issue=8 |pages=683–8 |year=1994 |month=August |pmid=7962615 |pmc=502135 |doi= |url=}}</ref><ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | *[[Meningioma]].<ref name=pmid7962615>{{cite journal |author=Ironside JW |title=Update on central nervous system cytopathology. II. Brain smear technique |journal=J. Clin. Pathol. |volume=47 |issue=8 |pages=683–8 |year=1994 |month=August |pmid=7962615 |pmc=502135 |doi= |url=}}</ref><ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | ||
*Neurofibroma.<ref name=pmid7962615/> | *[[Neurofibroma]].<ref name=pmid7962615/> | ||
*[[Schwannoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | *[[Schwannoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | ||
*Metastasis.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | *Metastasis.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | ||
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===Things that smear well=== | ===Things that smear well=== | ||
Dyscohesive tumours: | Dyscohesive tumours: | ||
*Lymphoma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | *[[Lymphoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | ||
*Pituitary adenoma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | *[[Pituitary adenoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | ||
*Oligodendroglioma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | *Oligodendroglioma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref> | ||
*[[Astrocytoma]]. | *[[Astrocytoma]]. | ||
Revision as of 15:10, 11 April 2011
CNS cytopathology is a subset of neuropathology and cytopathology.
An introduction to cytopathology is in the cytopathology article. Cerebrospinal (CSF) specimens are dealt with in a separate article called CSF cytopathology.
Basic approach
| CNS cytology | |||||||||||||||||||||||||||||||||||||||||
| Tumour | Non-tumour | ||||||||||||||||||||||||||||||||||||||||
| Glial | Non-glial | Infectious | Non-infectious | ||||||||||||||||||||||||||||||||||||||
| Glial | Non-glial | |
| Stranding (cytoplasmic) |
thin - cannot be seen at low power (2.5x obj.), true cytoplasmic processes |
thick - can be seen at low power (2.5x obj.), artifact of smearing |
| Edge of cluster | smooth/non-distinct | sharp |
Glial vs non-glial:
- Glial has ctyoplasmic processes/cytoplasmic strands (stringy processes) ~ 1 micrometer thick.
- They cannot be seen well at low power.
- Cotton candy-like appearance.
- Images:
Notes:
- Crush artifact (in smear preparation) can mimic glial processes.
- Crush artifact vs. real glial processes:
- No glial processes run perpendicular to the direction of smear.
- Glial processes may branch.
- Crushed/elongated nuclei are present in artifactual processes.
- Crush artifact vs. real glial processes:
Metastatic carcinoma
- Squamous cell carcinoma (ouhsc.edu).[2]
- Adenocarcioma (ouhsc.edu).
- Small cell carcinoma (ouhsc.edu).
Things that don't smear well
Cohesive tumours:
- Meningioma.[3][4]
- Neurofibroma.[3]
- Schwannoma.[4]
- Metastasis.[4]
Things that smear well
Dyscohesive tumours:
- Lymphoma.[4]
- Pituitary adenoma.[4]
- Oligodendroglioma.[4]
- Astrocytoma.
- Normal brain.
See also
References
- ↑ 1.0 1.1 URL: http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html. Accessed on: 2 November 2010.
- ↑ URL: http://moon.ouhsc.edu/kfung/JTY1/NeuroTest/Q92-Ans.htm. Accessed on: 3 November 2010.
- ↑ 3.0 3.1 Ironside JW (August 1994). "Update on central nervous system cytopathology. II. Brain smear technique". J. Clin. Pathol. 47 (8): 683–8. PMC 502135. PMID 7962615. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC502135/.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 252. ISBN 978-0387744858.