Difference between revisions of "Testicular adrenal rest tumour"

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'''Testicular adrenal rest tumour''', abbreviated '''TART''', is a rare tumour associated with increased ACTH, typically seen in the context of congenital adrenal hyperplasia.<ref name=pmid24967019>{{Cite journal  | last1 = Olpin | first1 = JD. | last2 = Witt | first2 = B. | title = Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia. | journal = J Radiol Case Rep | volume = 8 | issue = 2 | pages = 46-53 | month = Feb | year = 2014 | doi = 10.3941/jrcr.v8i2.1489 | PMID = 24967019 }}</ref>
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]]
| Subtypes  =
| LMDDx      = [[Leydig cell tumour]]
| Stains    =
| IHC        = melan A +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[testis]]
| Assdx      = congenital adrenal hyperplasia
| Syndromes  =
| Clinicalhx =
| Signs      = testicular masses (bilateral)
| Symptoms  =
| Prevalence = extremely rare
| Bloodwork  = serum ACTH elevated
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Testicular adrenal rest tumour''', abbreviated '''TART''', is a rare tumour associated with increased adrenocorticotropic hormone (ACTH), typically seen in the context of congenital adrenal hyperplasia.<ref name=pmid24967019>{{Cite journal  | last1 = Olpin | first1 = JD. | last2 = Witt | first2 = B. | title = Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia. | journal = J Radiol Case Rep | volume = 8 | issue = 2 | pages = 46-53 | month = Feb | year = 2014 | doi = 10.3941/jrcr.v8i2.1489 | PMID = 24967019 }}</ref>


==General==
==General==

Revision as of 02:21, 15 July 2015

Testicular adrenal rest tumour
Diagnosis in short
LM nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) nuclear atypia
LM DDx Leydig cell tumour
IHC melan A +ve
Site testis
Associated Dx congenital adrenal hyperplasia
Signs testicular masses (bilateral)
Prevalence extremely rare
Blood work serum ACTH elevated

Testicular adrenal rest tumour, abbreviated TART, is a rare tumour associated with increased adrenocorticotropic hormone (ACTH), typically seen in the context of congenital adrenal hyperplasia.[1]

General

  • Very rare.

Clinical:

  • Serum ACTH elevated.

Gross

  • Bilateral testicular masses.

Microscopic

Features:

  • Nests of eosinophilic cells interspersed with thin bands of fibrous tissue.
  • Mild (endocrine) nuclear atypia.

DDx:

Images

IHC

  • Melan A +ve.[2]

See also

References

  1. ↑ Olpin, JD.; Witt, B. (Feb 2014). "Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia.". J Radiol Case Rep 8 (2): 46-53. doi:10.3941/jrcr.v8i2.1489. PMID 24967019.
  2. ↑ Mizukami, H.; Hamamatsu, A.; Mori, S.; Hara, S.; Kuroda, M.; Nagai, T.; Fukunaga, T. (Mar 2011). "Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year.". Forensic Sci Int 206 (1-3): e71-5. doi:10.1016/j.forsciint.2010.09.017. PMID 20951518.
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