Difference between revisions of "Lymphocytic interstitial pneumonia"
Jump to navigation
Jump to search
(split out) |
|||
| Line 19: | Line 19: | ||
*No [[vasculitis]]. | *No [[vasculitis]]. | ||
*No [[necrosis]]. | *No [[necrosis]]. | ||
DDx: | DDx: | ||
| Line 29: | Line 25: | ||
*Nodular lymphoid hyperplasia. | *Nodular lymphoid hyperplasia. | ||
**This is determined in part by radiology; it has nodules radiographically. | **This is determined in part by radiology; it has nodules radiographically. | ||
===Images=== | |||
www: | |||
*[http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)]. | |||
*[http://path.upmc.edu/cases/case176/micro.html LIP (upmc.edu)]. | |||
==Stains== | ==Stains== | ||
Revision as of 06:35, 9 December 2014
Lymphocytic interstitial pneumonia (abbreviated LIP), also known as lymphoid interstitial pneumonia and lymphocytic interstitial pneumonitis, is an uncommon diffuse lung disease.
General
- Associated with autoimmune disorders (rheumatoid arthritis, pernicious anemia, Sjoegren syndrome)[1] and immunodeficiency.[2]
- Associated with viral infections (HIV, EBV, human T-cell leukemia virus (HTLV) type 1).
- Considered an AIDS-defining diagnosis.[3]
Gross
- Location: basilar predominance.
- Increased interstitial markings.
Microscopic
Features:[4]
- Small mature lymphocytes (usually B cells)[5] in the interstitium of the lung.
- Plasma cells.
- +/-Lymphoid follicles.
Negatives:
- No vasculitis.
- No necrosis.
DDx:
- Lymphoma.
- Follicular bronchitis/bronchiolitis.
- Nodular lymphoid hyperplasia.
- This is determined in part by radiology; it has nodules radiographically.
Images
www:
Stains
To exclude infection:[6]
- GMS stain -ve.
- Ziehl-Neelsen stain -ve.
IHC
- May be done to exclude lymphoma.
See also
References
- ↑ URL: http://emedicine.medscape.com/article/299643-overview. Accessed on: 2 June 2010.
- ↑ Nicholson AG (August 2001). "Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung". Semin Respir Crit Care Med 22 (4): 409–22. doi:10.1055/s-2001-17384. PMID 16088689.
- ↑ Turner, BJ.; Eppes, S.; McKee, LJ.; Cosler, L.; Markson, LE. (Jan 1995). "A population-based comparison of the clinical course of children and adults with AIDS.". AIDS 9 (1): 65-72. PMID 7893443.
- ↑ URL: http://emedicine.medscape.com/article/299643-diagnosis. Accessed on: 2 June 2010.
- ↑ AFIP atlas of nontumour pathology. 2002. Vo. 2. P.265. ISBN 1-881041-79-4.
- ↑ URL: http://path.upmc.edu/cases/case176/dx.html. Accessed on: 8 January 2012.