Difference between revisions of "Succinate dehydrogenase"
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'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria. | '''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria. | ||
==Immunostain== | |||
*It is used to look for mitochondrial disease. | |||
*Loss of staining is pathologic. | |||
==Associated pathology== | |||
Mutations in SDH genes are associated with: | |||
*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref> | *[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref> | ||
*[[Pheochromocytoma]].<ref name=pmid24500761/> | *[[Pheochromocytoma]].<ref name=pmid24500761/> | ||
Revision as of 05:54, 27 October 2014
Succinate dehydrogenase, abbreviated SDH, is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.
Immunostain
- It is used to look for mitochondrial disease.
- Loss of staining is pathologic.
Associated pathology
Mutations in SDH genes are associated with:
See also
References
- ↑ 1.0 1.1 Vicha, A.; Taieb, D.; Pacak, K. (Jun 2014). "Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.". Endocr Relat Cancer 21 (3): R261-77. doi:10.1530/ERC-13-0398. PMID 24500761.
- ↑ Ricketts, CJ.; Shuch, B.; Vocke, CD.; Metwalli, AR.; Bratslavsky, G.; Middelton, L.; Yang, Y.; Wei, MH. et al. (Dec 2012). "Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.". J Urol 188 (6): 2063-71. doi:10.1016/j.juro.2012.08.030. PMID 23083876.