Difference between revisions of "Chondroblastoma"
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Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref> | Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref> | ||
*Abundant extracellular material - pink on [[H&E stain]] - looks vaguely like cartilage. | *Abundant extracellular material - pink on [[H&E stain]] - looks vaguely like cartilage. | ||
*Sometimes described as 'immature cartilage' (very narrow DDX for this type of cartilage) | |||
*Chondroblasts: | *Chondroblasts: | ||
**Nuclear morphology variable: ovoid, folded or grooved. | **Nuclear morphology variable: ovoid, folded or grooved. | ||
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*+/-[[Giant cells]]. | *+/-[[Giant cells]]. | ||
**May lead to confusion with ''[[giant cell tumour of bone]]''. | **May lead to confusion with ''[[giant cell tumour of bone]]''. | ||
**Not infrequently associated with an aneurysmal bone cyst.<ref>{{Cite journal | last1 = Sepah | first1 = YJ. | last2 = Umer | first2 = M. | last3 = Minhas | first3 = K. | last4 = Hafeez | first4 = K. | title = Chondroblastoma of the cuboid with an associated aneurysmal bone cyst: a case report. | journal = J Med Case Rep | volume = 1 | issue = | pages = 135 | month = | year = 2007 | doi = 10.1186/1752-1947-1-135 | PMID = 17999776 }}</ref> | |||
DDx: | DDx: | ||
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*[[Chondroma]]. | *[[Chondroma]]. | ||
*Well-differentiated [[chondrosarcoma]]. | *Well-differentiated [[chondrosarcoma]]. | ||
*Chondromyxoid fibroma - also has 'immature cartilage' | |||
*[[Aneurysmal bone cyst]] - dont forget that these may be secondary to another lesion. | |||
===Images=== | ===Images=== | ||
| Line 64: | Line 68: | ||
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC) | Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC) | ||
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC) | Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC) | ||
Image:Bone Chondroblastoma Medium Power.jpg|Chicken wire calcification. (SKB) | |||
Image:Bone Chondroblastoma High Power.jpg|Chicken wire calcification. (SKB) | |||
Image:Bone Chondroblastoma With Aneurysmal Bone Cyst - Medium Power.jpg|Immature cartilage (left) abutting aneurysmal bone cyst (right) with giant cells. (SKB) | |||
Image:Bone Chondroblastoma - Medium Power.jpg|thumb|Immature cartilage]] | |||
Image:Bone Chondroblastoma and Aneurysmal Bone Cyst Low Power.jpg|Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB) | |||
Image:Bone Chondroblastoma and Aneurysmal Bone Cyst Low Power.jpg|Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB) | |||
</gallery> | </gallery> | ||
www: | www: | ||
Revision as of 07:06, 20 October 2014
| Chondroblastoma | |
|---|---|
| Diagnosis in short | |
 Chondroblastoma. H&E stain. | |
|
| |
| LM | abundant (chondroid) extracellular material, chondroblasts (variable nuclear morphology (ovoid, folded or grooved), moderate-abundant eosinophilic cytoplasm), +/-calcifications surrounding the cell nests ("chickenwire" appearance) - classic feature, +/-giant cells |
| LM DDx | giant cell tumour of bone, chondroma, well-differentiated chondrosarcoma |
| Site | growth plate - see chondro-osseous tumours |
|
| |
| Clinical history | "young" - growth plates open |
| Symptoms | painful |
| Prognosis | benign |
Chondroblastoma is a benign chondro-osseous tumour that afflicts the young (growth plates open).
General
- Growth plate lesion.
- Sclerotic margin.
- "Young" = growth plates open.
- Typically painful.[1]
Gross
- Well-defined lesion.
Image
Microscopic
Features:[2]
- Abundant extracellular material - pink on H&E stain - looks vaguely like cartilage.
- Sometimes described as 'immature cartilage' (very narrow DDX for this type of cartilage)
- Chondroblasts:
- Nuclear morphology variable: ovoid, folded or grooved.
- Moderate-abundant eosinophilic cytoplasm.
- +/-Calcification surrounds the cell nests ("chickenwire" appearance) - classic feature.
- Cell nests have a thin pale blue rimming.
- +/-Giant cells.
- May lead to confusion with giant cell tumour of bone.
- Not infrequently associated with an aneurysmal bone cyst.[3]
DDx:
- Giant cell tumour of bone.
- Chondroma.
- Well-differentiated chondrosarcoma.
- Chondromyxoid fibroma - also has 'immature cartilage'
- Aneurysmal bone cyst - dont forget that these may be secondary to another lesion.
Images
Chondroblastoma - intermed. mag. (WC)
Chondroblastoma - very high mag. (WC)
Chicken wire calcification. (SKB)
Chicken wire calcification. (SKB)
Immature cartilage (left) abutting aneurysmal bone cyst (right) with giant cells. (SKB)
Immature cartilage]]
Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB)
Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB)
www:
- Chondroblastoma (medscape.com).[4]
- Chondroblastoma with "chickenwire" appearance (medscape.com).[4]
- Chondroblastoma (upmc.edu).[5]
IHC
Features:[2]
- S100 +ve.
- Vimentin +ve.[4]
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 625. ISBN 978-1416054542.
- ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 642. ISBN 978-0781765275.
- ↑ Sepah, YJ.; Umer, M.; Minhas, K.; Hafeez, K. (2007). "Chondroblastoma of the cuboid with an associated aneurysmal bone cyst: a case report.". J Med Case Rep 1: 135. doi:10.1186/1752-1947-1-135. PMID 17999776.
- ↑ 4.0 4.1 4.2 URL: http://emedicine.medscape.com/article/1254949-diagnosis. Accessed on: 31 December 2010.
- ↑ URL: http://path.upmc.edu/cases/case494.html. Accessed on: 24 January 2012.